| Penicillin is the earliest discovered beta-lactam antibiotic and first applied toclinical therapy in the1940s. Cephalexin is also a kind of beta-lactam antibiotic whichis commonly used in clinical. These two drugs have obvious inhibition efficacyagainst grand positive bacteria, and are considered as effective treatment for manyinfectious diseases. They both play an important role in clinical application because ofgood dispersion, low toxicity and high efficiency.Raman spectroscopy is an effective method to study the material structure whichhas been widely used in materials, chemical, oil, biological, environmental protection,etc. Surface Enhanced Raman Spectroscopy (SERS) is a kind of very good surfaceanalysis method. Its high surface and interface sensitivity and detection sensitivityresult in the widely application.This paper mainly carries out a work that about the application of Ramanspectrum and surface enhanced Raman spectroscopy in the study of penicillin andcephalexin drugs. This study will broaden the application of Raman spectrumtechnology in the drugs. The main works are summarized as follows:Apply Raman spectrum to study the stability of penicillin drugs. This part aimedto research the stability of penicillin sodium solution in different pH value. By gettingreal-time Raman spectrum, this paper carries on the preliminary discussion about thisquestion from the point of spectral image. Combining with principal componentanalysis method, this paper receives a further result about the degradation process ofpenicillin sodium solution. Finally, this paper realizes the qualitative analysis of thestability in penicillin drugs.Apply a new active substrate in Surface Enhanced Raman Spectroscopy. Byusing graphene oxidation, this paper carries out an applied research in the field ofSurface Enhanced Raman Spectroscopy. The result shows that this new activesubstrate can enhance the Raman signal of dye rhodamine6G, industrial chemicalmelamine and cephalexin antibiotic to a certain extent. Finally, it carries out adiscussion about the enhancement mechanism of graphene oxidation. |
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