Synthesis And Properties Of Multifunctional Hierarchical Porous Bioactive Glasses

Nowadays, as a novel bioactive materials, bioactive glasses(BGs) have beenwidely used for bone replacing and repair. With the requirement for bone repairmaterials being more and more increasing, the traditional BGs can not meet the needs ofpeople. And, considering the criterion of ideal materials for bone repair, the functionalmultilevel-pore materials developed rapidly. At present, two methods for making BGsfunctional: BGs were modifed by dopping others and composited with the organicmaterials. Herein, based on the traditional BGs, the magnetic multilevel-pore BGs andBGs/organic multilevel-pore material were considered as good functional results. Also,the various modern testing techniques are used to characterize the as-synthesizedsamples, such as scanning electron microscope (SEM), X-ray diffraction (XRD),nitrogen adsorption–desorption, magnetic hysteresis curve, contact angle and so on.Additional, the drug storage/release and the bioactivity in vitro of the materiasls havebeen investigated. The main study is as follows:(1) The magnetic and macro/mesoporous bioactive glasses (MMBGs) weresynthesized by one-pot method via filtrated suitable salt crystal as the macroporoustemplates and nonionic triblock copolymer (P123) as the mesoporous template andreducant. In addition, the influence of calcining time in air on the mesoporous structureand the formation of Fe3O4were also discussed. The objective of this work is tosynthesize hierarchically porous bioglasses with unique porous structure and excellentproperties. Simultaneously, the drug delivery and biomineralization in vitro as well asthe biocompatibility assessment were studied in detail.(2) The electrospinning method was used to fabricate hierarchical porous fiberscaffolds with mesoporous bioglasses (MBGs) and poly acid (PLA). The influence ofthe amount of added MBGs on the formation of mesoporous structure in this syntheticsystem was considered. Meanwhile, the drug release behavior and release mechanism,as well, the biomineralization in vitrothe of fabricated MBGs/PLA was investigated.(3) One-pot method was used to fabricate composite porous fiber scaffolds with theelectrospinning technology by the acid volatile process. This method was certain to be green and environmental friendly. And the hydrophobic and hydrophilic performance,drug release and the biomineralization in vitro of the composite porous fiber scaffoldswere investigated.The results indicate that the obtained functional, hierarchically porous bioglassesshowed good drug loading/release and fast inducing-growth of hydroxyapatiteproperties. Thus, these materials can be an ideal candidate for clinical bone tissuerepairment and substitute.