Studies On Transition-metal-catalyzed Formation Of C-O And Desulfurization Arylation

Esters are widely exisited in natural products with physiologicalactivity or pharmacological activity and non-natural molecules containthe fragment, so the synthesis of esters has been explored by manychemical workers. The formation of C-O bond occupies a certaindominant position, while it is the research interest of a lot of organicchemists to achieve the formation of C-O bond by the activation of C-Hcatalyzed by transition metals. Currently, it is also one of the mosteffective and powerful method in the development of organic chemistry.The transition metal catalyzed aryl sulfide desulfurization to build theC-C bond also has been a research focus.In the first Part, we reviewed the research progress of the formationof C-O bond by activation of C-H bond catalyzed by transition metals. In the second Part: the esterification reaction of2-arylpyridines withsodium aryl formate was explored. We used2-arylpyridine and sodiumaryl formate as the substrates to realized C-H bond activation to constructthe C-O bond, in the condition of the copper salts as the catalyst, andK2S2O8as the oxidaiton. Moreover, we investigated the reactionmechanism preliminarily.In the last Part: We investigated the arylation reaction ofdesulfurization of sodium arylalkylene catalyzed by the palladium. Thereaction is to realize the arylation of acetanilide by removaling SO2fromarylalkylene sodium, and still under being explored, yield60%currently.