Total Synthesis Of Natural Product Antofine

This paper described the work of the total synthesis of antofine, based on the previous work in other groups, we designed two ways to achieve this alkaloid, Followed by a large number of experiments, we successfully completed the total synthesis of antofine. This thesis is divided into the following three chapters:Chapter I:A brief review on the significance of total synthesis of antofine and the molecular structural features of antofine. Inspired by the previous work in other groups which have done in the total synthesis of antofine, which we finally use in our strategy.Chapter2:According to previous research experience in other groups, we propose the strategy through a convergent synthesis, the use of multi-step condensation reaction to get the substrate azido phenanthrocyclopentanone through various efforts, but the Schmidt reaction apply in our strategy is failure.Chapter3:Learn from the failures of the first strategy, we changed the carbonyl position for the study of the Schmidt process. To learn more from a mature line connected, we finally achieved the target material through modify the structure of phenanthrene ring skeleton.