New Reactions Of The Transformation Of Organic Functional Groups Catalyzed By Transition Metals

Transition metals catalyzed C-C bond formation is one of the hotspots of Organic Chemistry. There are various types of transitionmetal-catalyzed reactions, such as Suzuki coupling, Negishi coupling, bifunctional reaction and so on. These reactions are able to introduce a variety of functional groups with high efficiency and atom economic advantages. But now, the transition metal catalyzed process requires a large number of complex ligands, which is difficult to separate and re-use. The shortcomings have limited the use of a transition metal catalyst. Therefore, our group focused on addressing these shortcomings through nano catalysts. This thesis discussed some meaningful results, including:1. Section I:This section describes the investigations on TBAB stabilized nano palladium-catalyzed Negishi coupling reactions to ketones. Section II:It describes the investigations on the difunctional additions of PhI(OAc)2-TBAB to activated olefins catalyzed by copper acetate. This reaction are highly chemical selective, regio-selective and stereo-selective. This reaction has high application value because it can introduce two different functional groups simultaneously.2. The section describes the investigations on new tea bags synthesis catalyst and its catalytic ability for the Suzuki coupling reaction. This newly developed catalyst is simple, easy to separate and reusable. We made the "Tea Bag" catalyst and analyzed its physical characterization. Further investigations on Suzuki coupling reaction showed that it was an excellent catalyst with100%yield and the catalyst could be reused for more than10times without the decrease of yields."Tea Bag" catalyst is not only facile in preparation, large surface area, environmental protection, but also solve the separation of catalyst and product and catalyst reuse.3. Section I:The section describes the investigation of the transition metal catalyzed oxidation of cyclohexene to prepare2-cyclohexenone and2-cyclohexenol. It provided an easy way to produce2-cyclohexenone derivates with a high conversion and selectivity. Section II: acetate, copper-manganese dioxide joint catalyzed dehydration of aldoximes to nitrile. The reaction was green, simple and efficient. The detailed investigations of the reaction mechanisms discovered copper acetate catalyzed Beckmann rearrangement in water.In conlusion, the transition metal catalyzed reactions are able to build a variety of useful skeletons. Therefore, it is a meaningful job to investigate and to expand their applications.