BF₃Et₂O-catalyzed Synthesis Of Naphthalene Derivatives And Copper-catalyzed N-arylation Reaction Of Nitriles

With the development of C-C, C-heteroatom bond formation catalyzedby Lewis acids and transition metals, it becomes probable or easy tosynthesize some of complicated drug molecules and natural products.Therefore, development of new catalytic reactions arouses the interest ofmany organic chemists and pharmacists. In this dissertation, two kinds ofnew catalytic reactions will be reported by us.In the second chapter, an inexpensive BF₃Et₂O-catalyzed annulation r-eaction of aryl-acetaldehydes with aryl-alkynes has been introduced. Vario-us substituted phenyl-acetaldehydes and phenyl-acetylenes can undergo thisreaction, producing corresponding α-aryl substituted naphthalene derivativ-es. Use of inexpensive and readily available BF₃Et₂O catalyst constitutesthe most attractive advantage of this transformation.In the third chapter, we developed a copper catalyzed coupling reactionof aryl halides with nitriles. This transformation resized N-arylation of nit-riles to get the N-aryl amides overcame the shortage of Ritter reaction. Va-rious of N-aryl amides can be synthesized by this approach.