The Preparation And Characterization Of Transdermal Absorption Materials

The study on the preparation and the characterization of the transdermal absorption materials has been completed in this paper.The sponge-like dressings based on CS, SA and SH were prepared by freeze-drying an aqueous solution of the three macromolecule compounds. The response surface method was used to study the influence among the stirring speed, the percentage of SH and the ratio of CS and SA on the tensile strength of CS spongy composite. The factors and levels of the experiment was determined based on the results of single factor test. According to the design principle of the central composite experimental of Box-Benhnken, the optimum process conditions for the preparation of CS spongy composite was determined by the response surface method that with three factors and three levels based on the single factor test, response surface and contour curve with the tensile strength of the spongy composite material as the response value was mapped. The optimum process conditions for the preparation of CS spongy composite was determined by response surface method. The best conditions were the ratio of CS and SA=3.71:1, SH concentration=14%, the stirring speed=541r/min. Under the best conditions, the theoretical tensile strength was0.1652MPa. The results showed that:the influence and interrelated influence from stirring speed, percentage of SH and the ratio of CS and SA on the tensile strength of the spongy composite were intuitive analyzed by the response surface method. Compared with the ratio of CS and SA, the stirring speed and the percentage of SH have greater effect on the tensile strength of the CS spongy composite.The CS spongy composite which were prepared based on the best conditions were characterized by IR, SEM and TG; the tensile strength, water-absorbing quality and water-retaining property of the CS spongy composite were researched; the biological safety evaluation experiment like the cytotoxicity test, skin irritation and allergy test were given on the CS spongy composite. The results showed that:the CS spongy composite has porous and multi-level structure, the practical tensile strength was0.1709Mpa; it was also has the good water-absorbing quality, water-retaining property and acid and alkali resistance. The results of the biological safety evaluation experiment showed that the CS spongy composite has A good biological activity and can meet the requirements of medical dressings. In vitro transdermal experiments showed that the cumulative transdermal release dosage curve of flurbiprofen axetil(FA) was accord with the law of transdermal drug absorption; the duration time of In vitro transdermal process was more than24hours, it means the CS spongy composite has a good sustained release effect; the permeability of FA has been reach9.2%, that means the percutaneous permeability of the CS spongy composite was good.The FA transdermal patch was designed based on the CS spongy composite playing a role as sustained release materials in this paper. The structure of the FA transdermal patch is simple and it is easy to use. With the sustained release layer that was made up by the CS spongy composite which has has porous and multi-level structure, the liquid can through the skin gradually, and then achieving the sustained release effect. In addition, the FA transdermal patch with the CS spongy composite also can achieve the treatments such as analgesia action, anti-inflammation, anti-bacterial, and healing wounds effect.