Copper-catalyzed Dehydrogenative Reaction:Synthesis Of Amide From Aldehydes And Aminopyridine

In this dissertation, we reported the one-pot cooper catalyzed direct aerobic oxidative process to form amide bond. This dissertation includes four chapters as follows.Chapter1reviewed the importance of heterocyclic compounds, including their significance in pharmaceutical, natural products and electroactive materials. Then introduce the impressive achievements of direct sp2C-H bond transformation of heteroaromatics.Chapter2mainly introduced the recent advances in the transition metal catalyzed oxidative C-H bond activation strategy for C-C and C-N bond formation. Elaborating the dehydrogenative direct coupling reaction of heteroarenes, including arylation, olefination, alkynylation, and amination/amidation utilizing transition metal catalysts.Chapter3introduced the recent developments in the methods of amidation reaction and the importance of the synthesis of amides.Chapter4elaborated a highly efficient method in the presence of cooper catalyst to form amides from aminopyridines and aldehydes. This method is simple, environmental benign and has practical advantages in the amide synthesis.