Iron(Ⅲ)-Catalyzed Synthesis Of Multi-substituted Imidazoles

The thesis consists of three chapters.In the first chapter, because of its unique structure and drug activity, Multi-substituted Imidazoles attracted the extensive attention of the biologists, chemists and pharmacologist. So far, they have not been isolated from natural products, but a large number of synthesis method of Multi-substituted Imidazoles has been found and developed. In this paper, we will summarize and review the different artificial synthesis.In the second chapter, A novel and efficient iron(III)-catalyzed synthesis of multi-substituted imidazoles via [3+2] cycloaddition of nitroolefins and N-aryl benzamidines under the air atmosphere had been developed. This methodology is conveniently, atom-economical, general, and eco-friendly in good yields and prefect regioselectivities.In the third chapter, A novel and efficient iron(III)-catalyzed synthesis of1,2,4-trisubstituted imidazoles through the reactions of amidines and aldehydes in air had been developed. Five hydrogen dissociations involving C-H and N-H bonds activation are realized under mild conditions in this approach. The procedure is sustainable, simple and environmentally friendly.