Research Of The Relation Between Iodine Nutrition Level、sodium/Iodide Transporter And Differentiated Thyroid Carcinoma

Objective:Discuss the relation of Iodine and differentiated thyroid cancer; Acquaintance of different regions and different level of iodine nutrition, the expression of sodium/iodide transporter in differentiated thyroid cancer.Method:1) Combine the historical data and preinvestigation, we set Pingtan county and Yongtai county of Fuzhou city as the High iodine area and adaptive iodine area of the epidemiology investigation, collect the Morning fasting urine specimens of the local junior students, then we got the Determination of urinary iodine by arsenic-cerium catalytic spectrophotometry value. Gather the detial data of these two region s incidence of thyroid cancer after the national iodine from Fujian tumor prevention and treatment center.2)Select the patients in our hospital diagnosed with differentiated thyroid cancer during2010.07-2012.12, and divide them into Group Pingtan county and Group Yongtai county, use the method of Immunohistochemical to determine the expression of the patient s cancer tissue, tissue adjacent to cancer, Sodium/iodine transporter in lymph node metastasis. Result:1)The Pingtan county’s Iodine nutrition level is higher than the Yongtai county’s in2011(281.3±171.9μg/L VS151.4±77.2μg/L, P=0.00); The Differentiated thyroid cancer incidence rate in an average annual of high iodine area (the Pingtan county) is much higher than the adaptive iodine area(the Yongtai county) from2001to201162.72/1010000vs1.84/101000, P=0.00); The incidence rate of women with differentiated thyroid cancer is always higher than the rate of men, moreover, the ratio of high iodine area is much higher (P=0.02). Compared with the adaptive iodine area(the Yongtai county), the proportion of differentiated thyroid carcinoma of the high iodine area (the Pingtan county) is much higher (98.5%vs91.0%, P=0.00),and the papillary carcinoma makes the majority (95%vs83.3%, P=0.03), while the undifferentiated carcinoma is more rare.(0.1%vs1.3%, P=0.00)2) Compared with the thyroid tissue adjacent to cancer, the expression of sodium/iodine transporter in thyroid cancer tissue is higher.(83.3%vs60.0%, P=0.01)。The expression of Sodium/iodine transporter in thyroid cancer is higher than Lymph node metastasis (83.3%vs60%, P=0.01) moreover the strong positive expression ratio is much higher (66.0%vs14.3%, P=0.00), while the result expression of tissue adjacent to cancer and Lymph node metastasis in sodium/iodine transporter were similar. Further stratified analyses shows that the expression differences of sodium/iodine transporter in patient’s Tissue adjacent to cancer, cancer tissue, lymph node metastasis under the different levels of Iodine nutrition from different region (Pingtan county and Yongtai county) do not have statistical significance (P>0.05)Conclusion:The incidence of differentiated thyroid cancer of the high iodine area and adaptive iodine area are both increased, however, the incidence of high iodine area is much higher than the adaptive iodine area’s, and it is more common in women. The Increasing trend of cancerous goiter is mainly in differentiated thyroid cancer, especially in the papillary carcinoma, while the undifferentiated carcinoma becomes more rare. This trend is especially obvious in the high iodine area. Sodium/iodine transporter in differentiated thyroid cancer is overexpressed, Primary focal expression is higher than the rate of lymph node metastasis, the two are mainly expressed in the cytoplasm. the expression differences of sodium/iodine transporter in patient s Tissue adjacent to cancer, cancer tissue, lymph node metastasis under the different levels of Iodine nutrition from different region (Pingtan county and Yongtai county) do not have statistical significance.