Analysis Of Clinical Characteristics And Treatment Methods Of Acute Fatty Liver Of Pregnancy

Objective: to analyze and summarize the clinical features of acute fatty liver (markers)during pregnancy and treatment outcome, as markers of clinical diagnosis,progression and treatment experience of reducing maternal and perinatal mortality.Methods: collect state hospital in fujian province obstetrics between January2002and December2002, the clinical data of23patients with markers in hospital, to all ofthe patients medical history, clinical manifestation, auxiliary examination, diagnosis,termination of pregnancy and pregnancy outcomes were retrospectively analyzed.Results:(1) the survival of21patients with markers come on to see a doctor for anaverage7.5days,2cases of death in patients with onset and clinical time not less than2weeks. To see a doctor in1weeks time, patient survival rate was100%, more than2weeks or more mortality is higher.(2) confirmed to terminate the pregnancy time within24hours, and ALT,AST, TBIL, Cr after termination of pregnancy, APTT, HGB is lower than beforetermination of pregnancy, Fg levels higher than before the termination of pregnancy,the difference had statistical significance (P <0.05).(3) cesarean delivery of17cases of termination of pregnancy and vaginaldelivery6cases, including4cases of general anesthesia, waist hard joint anesthesia13cases, hysterectomy in3cases. Appear,15cases of postpartum hemorrhage ofcesarean section in9cases of postpartum hemorrhage and vaginal delivery in6casesof postpartum hemorrhage, there was no statistically significant difference (P>0.05).(4)6cases of combined multiple organ dysfunction syndrome aftercontinuous blood purification therapy in patients with AST, ALT, TBIL, Cr, PT,APTT, WBC than before blood purification, propagated, Fg, PLT level is higher than before the blood purification, difference have statistical significance (P <0.05).Conclusion: pregnancy with acute fatty liver is a kind of severe obstetriccomplications in late pregnancy, sudden onset, progress rapidly, so the treatmentshould be early diagnosis on termination of gestation time, try to shorten the onset todiagnosis, timely termination of pregnancy termination of gestation the best time for24~48h after diagnosis for multi-disciplinary comprehensive treatment, aftertermination of pregnancy for patients complicated with multiple organ dysfunctionsyndrome should be early blood purification therapy can significantly reduce maternalmortality.