The Influence Of β-catenin Expression On Biological Behavior Of Non-small Cell Lung Cancer

Objective The experiment was supposed to investigate the expression ofβ-catenin in non-small cell lung cancer and their correlation withclinicopathological features and prognostic significance.Methods The expression of β-catenin was detected in58specimens ofnon-small cell lung cancer tissues and17specimens of adjacentnon-cancerous lung tissues by immunohistochemicalmethod(MaxVisionTM method).Result The abnormal expression rate of β-catenin in non-small lungcancer tissues was significantly higher than that in adjacentnon-cancerous lung tissues(84.5％(49/58)vs47.1％(8/17) P<0.01). Theexpression of β-catenin correlated with tumor size,lymph nodemetastasis,TNM Stages,differentiation(p<0.05), but no correlated withage, sex, histologic subtyre(p>0.05).5years survival rates of β-cateninexpression were6%and38%in positive group and negative group,themedian survival time were22.5momths and34.5momths,all withstatistically significant (P<0.05);abnormal expression of β-catenin andⅢ+Ⅳ,lymph node metastasis,poorly differentiated all single factorsassociated with survival negative(P<0.05).Conclusion The expression of β-catenin in non small cell lung cancerwas more significantly up-regulated than in the adjacent normal lungtissue.The expression of β-catenin correlated with tumor size,lymph nodemetastasis,TNM Stages,differentiation(p<0.05),and negative correlationwith the survival rate and survival period.It’s show us that β-cateninexpression in non-small cell lung cancer may have some impacts on the occurrence, development of non-small cell lung cancer, therefore, in viewof β-catenin and its related signal pathway intervention research ofanti-tumor is expected to develop a new way of prevention and treatmentof lung cancer.