Effect Of Plasma CRP And Fib Of VCI After Cerebral Infarction Treatment With Transcranial Magnetic Stimulation

Objective To investigate the treatment effects of transcranial magneticstimulation (TMS) on vascular cognitive impairment (VCI) after cerebralinfarction patients and its impact with the content of plasma C-reactive protein(CRP) and fibrinogen (Fib), at the same time, discuss the relationship betweenCRP, Fib and VCI after cerebral infarction.Methods Selected102VCI after cerebral infarction patients who had beenhospitalized in the Department of Neurology of Ningxia Hui Autonomous RegionPeople’s Hospital during March2011to October2012, these diagnosis up to theVCI treatment standards that was established by the Dementia and CognitiveDysfunction Group of Chinese Medical Association Neuropathy Academy.Thepatients were divided into two groups: the treatment group of53patients and thecontrol group of49patients,and selected50healthy people as the normalgroup.The treatment group was treated with Xueshuantong injection+TMStherapy+regular treatment,the control group was treated with XueshuantongInjection+regular treatment,and the normal group was not treated.Before and aftertreatment,used the Montreal Cognitive Assessment(MOCA)and the Alzheimer’sDisease Assessment Scale-cognitive section(ADAS-Cog) to assess the patient’scognitive function in order to evaluate TMS’s treatment effect on VCI patientsafter cerebral infarction.Used turbidimetric immunoturbidimetry assay todetermine the content of plasma CRP and coagulation method for the content of Fib,compared the levels of plasma CRP and Fib of three groups,and analyzed therelationship between plasma CRP、 Fib and VCI after cerebral infarction.Results (1) Before the treatment,the levels of plasma CRP and Fib of thetreatment group and the control group increased significantly compared with theregular group (P<001);Before the treatment,the levels of plasma CRP and Fibshowed no significant differences between the treatment group and the controlgroup (P>0.05);After the treatment,the levels of plasma CRP and Fib of thetreatment group was lower than before (P<0.01);After the treatment,the levels ofplasma CRP and Fib of the control group decreased significantly than before(P<0.05);After the treatment,the levels of plasma CRP and Fib of the treatmentgroup decreased significantly(P<0.05).(2) Before the treatment,the MoCA and ADAS-Cog scores showed nosignificant differences between the treatment group and the controlgroup(P>0.05);After the treatment,MoCA score of the treatment group wassignificantly higher than before(P<0.01),while ADAS-Cog score of the treatmentgroup was significantly lower than before(P<0.01);There was an obviousincreasing of MoCA score between the treatment group and the controlgroup(P<0.05),ADAS-Cog score of the treatment group decreasedsignificantly compared with the control group(P<0.05).(3) The comparison of the treatment efficiency between the treatment groupand the control group: the total effective rate of the treatment group was75.47％,while the total efficiency of the control group was48.98％, it was significantlyhigher than the control group (P<0.01).(4) Through the pearson correlation analysis, the levels of plasma CRP andMOCA scores showed a negative correlation (r=-0.709， p<0.05), the higher thelevel of plasma CRP, the lower MOCA scores; the level of plasma Fib and MOCA scores showed a negative correlation (r=-0.644， p<0.05), the higher the level ofplasma Fib,the lower MOCA scores.Conclusion (1) the levels of plasma CRP and Fib of VCI after cerebralinfarction patients increased significantly, the levels of plasma CRP、 Fib and thepatients’ MOCA scores showed a negative correlation, reduce the levels of plasmaCRP and Fib have a certain clinical significance for prevention and treatment ofVCI.(2) TMS can reduce the levels of plasma CRP and Fib.(3) The TMS combination drugs have a significant effect on VCI aftercerebral infarction patients and worthy of being widely applied in clinic.