The Effect Of The Balanced Ultrafiltration To The Blood Lactic Acid Of Patients With Valvular Heart Disease During Cardiopulmonary Bypass

Objective To observe the effect of the balancedultrafiltration to the blood lactic acid of patients withvalvular heart disease during cardiopulmonary bypass.Methods Select60cases patients between the ages of45to70years old who accepting heart valves replacement in ourhospital from july2012to January2013. Divide the patientsinto two groups according to the number of hospitalized.Singular is the group of using ultrafiltration (group A), dualis the group of not using ultrafiltration. There are30casesin each group. Count all the patients’ date and record everyobservation target. Compare the preoperative, during the CPBand postoperative PO2, PCO2, serumal lactic acid，bloodglucose and BE（base excess） of group using ultrafiltrationand group not using ultrafiltration; Compare cardiopulmonarybypass time, aortic cross clamp time, urine output in the CPBand mechanical ventilation time of the two groups; Come toconclusion.Results Preoperative lactic acid had no significant difference in both groups (P>0.05); The30min,60min,90min’slactic acid in the CPB of the two groups have significantdifference compared with preoperative’s (P≤0.05);60min hassignificant difference compared with30min (P≤0.05),90minhas significant difference compared with60min (P≤0.05);Postoperative12h and postoperative24h compared with90minof the CPB have significant difference (P≤0.05); In groupA, there is no significant difference between12h and24hafter operation (P>0.05). In group B, there is significantdifference between12h and24h after operation (P≤0.05).The preoperative,CPB’s and postoperative blood oxygenpartial pressure, CO2partial pressure，blood glucose levelsand BE of the two groups have no significant difference.Conclusions1Cardiopulmonary bypass is not thephysiological blood circulation. That is unable to avoid therising of lactic acid;2As the CPB’s time extended, lacticacid showed a trend of rising;3Balanced ultrafiltration canreduce intraoperative lactic acid level;4Balancedultrafiltration can contribute to postoperative lactic acidlevel’s recovery.