The Pharmaceutical Research Of Effective Part Freeze-dried Power Injection Of Alternanthera Philoxeroides

Altemanthera philoxeroides [Altemanthera Altemanthera (Mart.) Griseb] is Amaranthaceae Altemanthera (Amaranthaceae)(Altemanthera) perennial herb. The medicinal herbs and its injection was recorded in Pharmacopoeia1977edition of "the people’s Republic of China", with clearing and detoxifying, cooling blood and diuretic efficacy. Our previous study on antivirus potential basis of Altemanthera philoxeroides, the effective material parts are flavonoids and saponins compounds; On this basis, the lab implemented reserch with Wuhan Hvsen Biotechology Co.LTD,intends to develop Alternanthera philoxeroides effective substance fractions extract to the traditional Chinese veterinary new drugs. Study on Preparation Of the freeze-dried powder of Material extracts of Altemanthera philoxeroides in this thesis, developed the preparation of quality standards and conduct preliminary investigation of stability, lay the foundation for the secondary development of Altemanthera philoxeroides injections.Use of Macroporous resin techniques, we get the Altemanthera philoxeroides effective parts extract and study on freeze-dried powder preparation process of Altemanthera philoxeroides effective parts, Prefer prescription composition and freeze-dried process parameters of preparations molding process.Use of modern analytical techniques, we study such as the traits、the TLC identification、the Check items (load difference、pH value、 reconstitution time、moisture) and determination of the effective fractions of extracts of Alternanthera philoxeroides, developed a moreimprove quality standards. Active ingredient content determination methods which with good reproducibility and reliability. It Can effectively control the quality of freeze-dried powder injection of Alternanthera philoxeroides effective parts.In accordance with the guiding principles of Chinese medicine natu-ral drug stability, the use of accelerated testing and at room temperature for two research methods, in accordance with the freeze-dried powder injection of Alternanthera philoxeroides effective parts above the quality standards developed for the detection basis of the the freeze-dried powder injection of Alternanthera philoxeroides effective parts, The stability of the drug were studied. The results show that,all the indexes did not change significantly,indicating that the stable quality of the freeze-dried powder injection of Alternanthera philoxeroides effective parts in the warranty period, which provides the basis for its clinical use.