The Study On The Application Of Surg.take To Peirtoneal Lavage In The Patients Taking With D2Radical Gastrectomy

BackgroundGastric cancer is one of the most common malignancy in the world, the morbidity andmortality Bureau malignancy in second place, China’s large and medium-sized cities, ruralareas first. The country each year about16million people died of stomach cancer,accounting for23%of cancer deaths. Chinese gastric cancer to prevent the currentsituation can be summarized as "three high and one low" characteristics: high morbidityand mortality, early diagnosis rate is low (only about10%of I), low surgical resection(radical resection rate of50%to60%),5-year production is low (about30%of the overallproductivity). Surgical treatment is still the only way to cure stomach cancer, D2standardradical surgery has been recognition by most scholars at home and abroad, and has beenrecommended USNCCN (the US National Comprehensive Cancer Network), but thereports in the literature, although the stage III gastric cancer patients subjected to D2or D2+even D3, D4radical surgery, the5-year productivity remains and30%, simply toimprove the resection is difficult to improve productivity, the local non-surgical treatmentof perioperative received increasing attention. Gastric intra-abdominal metastasis andrecurrence of the most common, affecting the productivity of the main factors of thestomach in patients after5years, postoperative abdominal metastasis rate from42.5%to61.5%, including70%who dies as a result of peritoneal metastasis, peritoneal metastasisperitoneal metastasis, abdominal lymph node metastasis and liver metastasis, which mostmajor peritoneal dissemination. The metastasis of factors, including tumor cell invasionserous shedding surgery operation to squeeze the lesion off, amputation specimens andvascular surgery with the digestive juices of the tumor cells, lymph or blood spilled intothe abdominal cavity and so on, surgery after completion of the abdominal washing, havean important role to prevent the remaining tumor cell metastasis.ObjectiveTo study the different effect of removing intraperitoneal exfoliated gastric cancer cellsby using Surg.take and saline in the peritoneal lavaging of the patients taken with D2radical gastrectomy.Materials and MethodsA retrospective study was performed to investigate200patients who underwent D2radical gastrectomy for gastric carcinoma from February2012to October2012. Patients inexperimental group use500ml Surg.take to peritoneal lavage after completing D2radical gastrectomy,and the others in control group use saline. To compare with positive rate ofintraperitoneal exfoliated gastric cancer cells before taking surgery、positive rate ofintraperitoneal exfoliated gastric cancer cells after taking surgery、negative conversion ratioof the positive patients after taking surgery、constituent ratio of pathological stage of thepatients.ResultsThere are27positive patients of intraperitoneal exfoliated gastric cancer cells beforetaking surgery、8positive patients of intraperitoneal exfoliated gastric cancer cells aftertaking surgery、19patients of turning negative after surgery in the experimental group；andthere are26positive patients of intraperitoneal exfoliated gastric cancer cells before takingsurgery、21positive patients of intraperitoneal exfoliated gastric cancer cells after takingsurgery、5patients of turning negative after surgery in the control group. The differences ofpositive rate of intraperitoneal exfoliated gastric cancer cells before taking surgery betweenthe two groups is not statistically significant(P=0.873>0.05). The differences of positiverate of intraperitoneal exfoliated gastric cancer cells after taking surgery between the twogroups is statistically significant(P=0.009<0.05). The differences of negative conversionratio of the positive patients after taking surgery between the two groups is statisticallysignificant(P=0.001<0.05).The differences of constituent ratio of pathological stage of thepatients between the two groups is not statistically significant(P=0.731>0.05).ConclusionsUsing Surg.take to peritoneal lavage can remove intraperitoneal exfoliated gastric cancercells effectively in the patients taken with D2radical gastrectomy,and improve the effect ofsurgery.