Research On The Expression Of CX43、MMP-7、TIMP-4Inacut Emyocardial Infarction

Background: Acute myocardial infarction is a serious disease which threatenshuman health, Patients often have a sudden onset, rapid progression seriousconsequences. Most scholars believe that this Related to Ventricular arrhythmiasCaused by CX43reconstruction. CX43is The most important connexin composed ofCardiac gap junction. Gap junction is a membrane structure,the Function is directcommunication between adjacent cells.Normal cardiac electro-mechanical activitydepends on the intercellular electrical coupling and chemical coupling, gap junctions isstructural basis. mediated by intercellular electrical coupling and chemical coupling.Recent studies have found that MMP-7, and their inhibitors TIMP-4is important toCX43reconstruction after myocardial infarctionObjective：In this study, detected expression of CX43, MMP-7, TIMP-4byimmunohistochemistry in normal myocardium and myocardial infarction.Observedexpression and correlation of CX43、 MMP-7,、TIMP-4. To reconstruction mechanismof CX43after acute myocardial infarction、the diagnosis of sudden cardiac deathCaused by Acute myocardial infarction、target therapy of Clinical provide experimentalbasis.Method： Selected40cases of autopsy specimens of Dalian Medical University,Department of Pathology and Forensic Medicine, these people died of acute myocardialinfarction;20non-cardiac cause of death as a control group of specimens. Detectedexpression of CX43, MMP-7, TIMP-4by immunohistochemistry in normalmyocardium and myocardial infarction.With SPSS18.0package for statisticalanalysis,the test indicators with the rank sum test, with spearman test analysis of thecorrelation.Result： Most of the CX43expression in Myocardial intercalated disc of normalmyocardium，lateral myocardial cells express very little, MMP-7low expression, TIMPhigh expression;CX43decreased expression in Marginal zone of acute myocardialinfarction and myocardial infarction, distribution of disorder. CX43decreased or disappeared at the cardiac intercalated disk. CX43scattered distributed in the cytoplasmand cardiac side, MMP-7expression was significantly increased, TIMP-4expressiondecreased；expression of three factors are differences Between different groups，spearman test statistical analysis showed that CX43expression negatively correlatedwith MMP-7and TIMP-4positive.after acute myocardial infarction.Conclusion：CX43redistribution in acute myocardial infarction related to theoccurrence of arrhythmia.MMP-7expression elevated、TIMP-4expression decreased In acute myocardialinfarction，May be related to the CX43redistribution.