The Analysis Of The Clinical Characteristics Of Immunoglobulin Light Chain Amyloidosis (AL) Cardiomyopathy

Objective: To improve the understanding of immunoglobulin light chain type(AL) amyloidosis cardiomyopathy by analyzing its clinical features.Material and methods: Study population was selected from our hospital during1995to2011. Retrospective analysis of the clinical characteristics,electrocardiogram,echocardiography laboratory tests and diagnostic method of immunoglobulin light chaintype (AL) amyloidosis cardiomyopathy.Results: Among the11cases of immunoglobulin light chain type (AL)amyloidosis cardiomyopathy.One patient had diagonsis of primary amyloidosiscardiomyopathy (9%),10patient had diagonsis of multiple myeloma withamyloidosis cardiomyopathy (91%).progressing heart failure was observed in all thesepatien. Electrocardiogram (ECG) showed that7patients were low voltage in the limbleads, echocardiography manifested that9patients were possessed with left ventricularhypertrophy as well as diffuse weakness of the wall motion.8patients had strongechocardiography light-spots in myocardium and a paucity of pericardial effusion.Among the11patients, one patient is still alive and under follow-up due to her shorttime of history. The other10patients died.Conclusion: The patients with immunoglobulin light chain type (AL) amyloidosiscardiomyopathy have few specific clinical features and poor prognosis.The patientswith multiple myeloma have worse prognosis,the echocardiography andelectrocardiogram of these patients often showed distinctive features,which can behelpful in diagnosis AL amyloidosis cardiomyopathy.