Analyze The Situation Of Newborn Hearing And Deafness Gene Screening In Tianjin

Objective:To report the work of newborn hearing screening in Tianjin. Discuss and analyze the meaning of deafness gene screening.In order to supply the defects of limitation in the hearing screening and improve the rate of deafness in children。In the same time, find the susceptible of deafness for targeted guidance and monitoring their hearing to reduce the incidence rate of deafness.Methods:Use the distortion product otoacoustic emissions (DPOAEs) to screening the newborn hearing born from2004to2012in Tianjin, in combination with the survey of high-risk.The babies that the result for refer or with the high-risk factors need to review in42days after their birth. The review of newborn hearing using DPOAEs combine with auto auditory brainstem response (AABR). The babies refer the review of newborn hearing need to doing hearing diagnostic tests in3months and6months after their born. The diagnostic tests using acoustic immittance, auditory brainstem response (ABR) and auditory steady state response (ASSR), the babies with hearing loss to wearing a hearing aid or the corresponding processing. From the2012, Tianjin begin the deafness gene screening, include the GJB2gene235delC,the SLC26A4gene IVS7-2A>G and the mitochondria12SrRNA1555A>G and1494C>T. The babies carry these gene to review hearing for DPOAEs and AABR, in the same time to told their parents how to protect their hearing and review hearing on a regular basis. For the refer babies doing hearing diagnostic tests to ensure the loss of hearing. Results:There are631927newborn babies accepted newborn hearing screening from2004to2012, the initial screening rates is74.15%,91912babies refer the hearing screening or with the high-risk factoes, the positive rate of initial screening is14.54%. There are40455babies accepted the review of hearing, the review screening rate are44.01%. From2009to2012,1489babies doing hearing diagnostic tests,984babies have hearing loss. After6months doing the hearing diagnostic tests are559babies,there are492babies have hearing loss. And138babies wearing a hearing aid, cochlear implantation are34babies. To the december2,2012,there are59861babies accepted deafness gene screening,2190babies carry the deafness gene, the rate of carry the deafness gene is3.66%. The GJB2gene235delC screening show there are8babies carry homozygous mutations,1142babies carry heterozygous mutation.For the SLC26A4gene IVS7-2A>G the result are8babies carry homozygous mutations,907babies carry heterozygous mutation. And14babies carry complex hybrid mutation in GJB2gene235delC and SLC26A4gene IVS7-2A>G.86babies have be found to be the mitochondria12SrRNA1555A>G homozygous mutations,17babies are heterozygous mutation.8babies are mitochondria12SrRNA1494C>T homozygous mutations,none has be found to be heterozygous mutation.601babies in these accepted the review of hearing,43babies in them doing hearing diagnostic tests,984babies have hearing loss.Conclusion:Newborn hearing screening is the effective way to early detection of hearing loss. Gene screening can find the vulnerable groups of hearing loss,so can make up for the shortage in newborn hearing screening. A combination of these can achieve the puepose of early discovery、diagnosis ang intervention treatment. Through the review heraing on a regular basis,the late onset in haering loss can be found eraly. And the same time, through to guide the drug use, movement way and fertility can reduce some of hearing loss or avoid the born of deaf children.