Quantitative Study In Vivo On Hemodynamics Downstream Of Mitral Vavle With Mitral Valve Replacement And Mitral Valvaloplasty

Objective:The purpose of this research was to take advantage of doppler echocardiography combined with computerized image analysis to contrast the effect that mitral valve replacement and mitral valvaloplasty interfere with the cardiac function and the hemodynamic actions downstream. To evaluate the effect of operation from fluid mechanics direction, for clinical provide rational choice of operation mode.Methods:44patients divided into five groups according to different operative method. LVEF. PGmean, Qmv, Vmax, ΔVmax were measued by Doppler echocardiography,TSS and Irei was computed by Doppler echocardiography combining with the analysis of image by computer. Make use of statistical methods and software to collate, contrast, analysis of the data in each group.Result:1. MVR with preservation subvalvular structure is good for the left ventricular function of patients. And the left ventricular ejection fraction(LVEF) is same to the MVP groups.(P>0.05).2. Mitral valve replacement (MVR) will cause valve downstream flow disturbance enhancement and flow field uniformity change. In the analysis of TSS and lrel, there was significant difference between MVR group and MVP groups (P<0.05).Conclusion:1. Bioprosthetic MVR or MVP is the best operation mode for mitral insufficiency, but the prosthetic valve narrow effect still cause valve downstream flow disturbance enhancement to produced TSS and lrel.2. Bioprosthetic MVR to retain the subvalvular structure can promote patient’s cardiac function, MVP is not to destroy the structure of the annulus, chordae, papillary muscle, It is conducive to the recovery of cardiac function in patients with.3. MVP is less affected the patients valve downstream hemodynamic.