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Design Of Photodynamic Therapy Of Tumors Control System Based On Embedded Linux System

Posted on:2014-09-01Degree:MasterType:Thesis
Country:ChinaCandidate:H WangFull Text:PDF
GTID:2254330401470197Subject:Communication and Information System
Abstract/Summary:PDF Full Text Request
Photodynamic therapy (PDT) is a new approach in the field of tumor treatment.Compared with traditional tumor treatment ethos, the PDT has the advantages of small sideeffects, targeting prospective etc. Combining with a variety of endoscopic,in the indicatestatus,the PDT treatment intraluminal tumor such as the digestive tract, respiratory tract andurinary tract etc,the effect of the PDT is notable. At the same time, the patients of tumor canavoid pain from surgical. The process of photodynamic therapy of tumors is long and slow. Inorder to make patients get the best treatment effect, the power and the illumination time werereasonable set in each treatment. At present, the confirmation of the power and theillumination time is usually base on clinical experience of doctor’s and the report ofpatients’physical examination. The doctor must have high level of business and increase theworkload. It is difficult for patients to get the best effect.In order to get the best therapeutic, this paper designed the control system ofphotodynamic therapy of tumors based on embedded Linux system. This system canautomatically measured Power density and illumination time according to the diameter oftumor, the location of the tumor, patients’ age, concentration of tissue oxygen. The doctorscan also adjust the data according to doctors’ clinical experience and the situation of patients.Before the treatment, the output value of power density is detected by the system’s powerdensity module. The optical fiber is guided to the inside body of patient’s by the endoscope.Then, dianosing and confirming the position of tumor based on the principle fluorescencediagnosis, treated with a laser.In this paper, the bladder tumor was selected as the object of research. First, check therelevant literature including the diagnosis and treatment of bladder tumor and photodynamictherapy. Then, analyz the characteristics and principle of endoscopic based on physiologicalstructure. The semiconductor laser with635nm wavelength was selected as a laser lightsource, the improved endoscope as medium of a guide optical fiber. Second, consulted therelated literature of fluorescence diagnosis, confirmed the PDD’s mechanism and operationprocess have no conflict with PDT. So PDD is introduced to this system used for tumordiagnose before the PDT treatment. The semiconductor laser with405nm wavelength is usedas the light source of PDD. Third, after compared and analyzed several microprocessor chips,the paper use ARM9series of S3C2440A as the core processor chip, the embedded system isintroduce into the terminal. Embedded systems are introduced into the system. Thermopileis used in the module of power density as sensor according to the actual need.At last, amethod was proposed, according the research results and the experimental data of BasicMedical PDT treatment of bladder tumors. Using this method, power density and illuminationtime can be determined by automatically measurement. The method is realized by softwareprogramming. At last, it has confrimed by clinical trials that this method has a good effect.
Keywords/Search Tags:Tumor, Photodynamic therapy, Sensor, Power density, Embedded system
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