IgA Nephropathy Patients In Blood And Urine Of Angiotensin, Transforming Growth Factor β1Changes And Its Significance

Objective: Discussed in the urine, blood and angiotensin conversion and growth factor β1(TGF-β1) in the IgA nephropathy patients in change and its significance.Methods:30patients with IgA nephropathy will according to the24h urine protein quantitative aredivided into group A (urine protein <24h.k25mg/g) and group B (25mg~50mg/24hurine protein, kg), group C (urine protein>50mg/24h.. kg); At the same time accordingto the result of renal biopsy in diagnosis into Ⅰlevel: most of the glomerulus is normal,occasional mild mesangial broadening (segments) with/without cell proliferation; Ⅱ, halfthe glomerular mesangial matrix or focal segmental sclerosis, rare small cresent; Ⅲ, mildto moderate diffuse mesangial cell proliferation and mesangial matrix broadening,occasional small new month and balloon adhesions; Ⅳ, severe diffuse mesangial cellproliferation and matrix hardening, some or all of the glomerular sclerosis, visible crescent(<45%); Ⅴ level: the lesion properties similar Ⅳlevel, but more severe,>45%glomerulus with crescent formation; Using enzyme-linked immunosorbent assay (ELISA)respectively to detect each patient’s blood in the urine and angiotensin and TGF-beta1,each patient’s serum creatinine levels.Result: Different clinical group, the blood in theurine, angiotensin, TGF-beta1level is significantly higher than control group (P <0.05);In different pathological group, the blood in the urine, angiotensin, TGF-beta1levelhigher than the control group (P <0.05).Conclusion: Angiotensin in blood, urine andTGF beta1changes in patients with IgA nephropathy is associated with the severity of thedisease. Can be used for clinical evaluation of IgA nephropathy progression andpathological changes provide important clinical basis.