Analysis For Recurrent Factors Of Primary Sacral Tumor Patients

Objective:To retrospectively investigate recurrent factors of primary sacral tumor after surgical treatmenL.Methods:we retrospectively reviewed the clinical data of39chordoma and giant cell tumor patients between2001.1～2011.3. Patient’s gender, age, tumor site, tumor size, course of symptoms, local invasion, type of surgery, type of tumor, and local recurrence were reviewed, and tumor site, tumor size, local invasion, type of surgery, type of tumor analyzed by Kaplan-Meier method, Log-rank test and COX regression model.The numeration data was analyzed by Chi-square or Fisher exact test.Results:There is the correlation of tumor invaded vertebrae site and type of tumor (p<0.05). The follow-up was8-146months, the mean was109.0months. The median tumor-free survival time was109.0±9.4months.11of39patients (28.2%) developed local recurrences, and3patients developed tumor-related death. Kaplan-Meier single factoranalysis displayed that invasion of the surrounding tissue, and surrgical type were the risk of the recurrence of sacral tumor after surgical treatment(P<0.05). CDFS had no significant difference with tumor size, type of tumor and tumor location (P>0.05). Multivariate analysis by COX regression model suggested invasion of the surrounding tissue (p=0.007) and type of surgery (p=0.011) were the independent prognostic factors.Conclusion:This trial indicated that only invasion of the surrounding tissue and type of surgery were shown to be independent predictors of prognosis of primary sacral tumor. For improving the prognosis of primary sacral tumor, en bloc resection of tumor is preferential treatment for chordoma patients; curettage combined inactivation can control the local recurrence and avoid surgery caused complication.