Outcomes Of134Adult-to-Adult Living Donor Liver Transplantation Recipients

Objective:With limitation of the supply of cadaveric liver, the adult living donor liver transplantation had been improving recent ten years. The objective of this study was to analyze the contributions of perioperative clinical factors to recipient outcomes in adult living donor liver transplantation (ALDLT).Methods:One hundred thirty-four ALDLT recipients transplanted at our center were studied with analysis of donor and recipient, graft and intraoperative variables. Cox regression models were used to examine the relationship of variables to the risk of graft failure.Results:Kaplan-Meier1-year and3-year recipient cumulative survival were93.2%and 83.7%, respectively and graft cumulative survival were91.7%and81.5%, respectively. In total, twenty-seven (18%) grafts failed. Ten patients died with a functioning graft. Other main causes of graft failure were vascular thrombosis (n=4) and recurrent HCC (n=3). Older recipient age (hazard ratio,1.45per10y;95%CI,1.19-1.62; P=0.014) and length of cold ischemia time (hazard ratio,1.13per h;95%CI,1.07-1.34; P=0.030) were significant predictors of graft failure. Recipient Model for End-stage Liver Disease score and graft size were not significant predictors.Conclusions:This single-center experience provides evidence that ALDLT is a viable option for liver replacement. Older recipient age and prolonged cold ischemia time increase the risk of graft failure.