Serum Chemerin、c-reactive Protein Level And Its Clinical Significance In Patients With Diabetic Nephropathy

Vessels complications were main hazards of diabetes mellitus,anddiabetic nephropathy was one of the most severe and common complications ofType2Diabetes Mellitus.In present,we found that adipocytokines,insulinresistance(IR), chronic inflammatory reaction，Type2Diabetes Mellitus andVessels complications of Type2Diabetes Mellitus has a close relationship andinteraetion.Multiple pathogenic mechanism the combined effect lead to diabeticnephropathy.Through measured serum chemerin、c-reactive protein levels ofType2Diabetes Mellitus、Diabetic Nephropathy and control groups andexplored the possible correlations between chemerin、c-reactive protein andDiabetic Nephropathy，and investigated the possible effect of chemerin andc-reactive protein levels in diabetes mellitus and diabetic nephropathy.Methods:60adult patients with type2diabetes mellitus enrolled betweenOctober2010and May2011.We divided it into two groups containing30caseson the basis of pure diabetes and Diabetic Nephropathy（all subjects did not haveother kidneys diseases）.We selected of the same period the healthy people of30cases as control group（without diabetes）. There is no difference between genderand age.Blood pressure，fasting plasma glucos（eFPG），glycosylated hemoglobin （HbA1c），low density lipoprotein cholesterol（LDL-C），high densitylipoprotein cholestero（lHDL-C），urea nitrogen（BUN），serum creatinine（Scr），chemerin and c-reactive protein（CRP）level were examined in three groups andanalyzed them relevance.Results:（1）The differences of FPG，HbA1c，LDL-C，HDL-C，BUN，Cr，chemerin，CRP level in three groups were statistically significan（tP＜0.05）；the differences between diabetes group、Diabetic Nephropathy group and controlgroup were statistically significant（P＜0.05）；the differences between DiabeticNephropathy group and diabetes group were statistically significant（P＜0.05）.（2）Simple linear correlation analysis shows，chemerin and FPG，HbA1c，LDL-C，BUN，Cr were positively correlated（r=0.513,0.294,0.151,0.523and0.652，P＜0.05），and HDL-C was negatively correlated（r=0.794，P＜0.05）；c-reactive protein is associated with FPG，HbA1c，LDL-C，BUN，Cr werepositively correlated（r=0.497,0.285,0.341,0.517and0.646，P＜0.05），andHDL-C was negatively correlated（r=0.687，P＜0.05）；Chemerin was positivecorrelation with c-reactive protein（r=0.712，P＜0.05）.Conclusions: The serum chemerin and C-reactive protein levels ofDiabetic nephropathies was increased，and serum chemerin，c-reactive proteinlevels is related to FPG，HbA1c，serum lipid，kidney；chemerin and CRP mayadjust the adipose cell formation and metabolic balance，insulin resistance，inflammation and endothelial cell damage mechanisms involved in DiabeticNephropathy development.