| Magnetic ordered mesoporous carbons (OMCs), due to high specific surface area, poresize distribution, large pore volume and good biocompatibility, had attracted greattechnological interest for the development of drug delivery, adsorption and separation,catalysis and other fields. Incorporation of metal elements such as Iron, aluminum, nickeland zinc, made the material much more interesting. Magnetic OMCs had potentialapplications in drug adsorption and desorption of heavy metals and environmental pollution.In this study, hard-templating and soft-templating method were used to synthesis magneticOMCs and the synthesised materials were characterized by X-ray diffraction (XRD),transmission electron microscopy(TEM), Nitrogen adsorption isotherms, etc. Theadsorption and desorption properties of magnetic OMCs on the five drugs (ibuprofen,aspirin, indomethacin, chloramphenicol and dynorphin A (1-13)) were investigated andevaluated.A simple and novel route was present to synthesize magnetic Fe-containing mesoporouscarbons by an incipient-wetness impregnation technique without using a solvent. By usingSBA-15as hard template, FeCl3as magnetic source and furfuryl alcohol as carbon source,magnetic OMCs were synthesized. The influence of the usage of FeCl3to the structuralparameters and the saturation magnetization strength, the ordering of the mesostructurewere investigated. The specific surface area and the total pore volumes decreased with theincreasing usage of FeCl3. The saturation magnetization strength could be easily adjustedby changing the usage of FeCl3in the synthesis. The specific surface area of thesynthesized magnetic OMCs was1471m2/g, with a pore volume of0.98cm3/g and poresize of3.4nm. The advantages of the method were that carbon sources could be completelyimpregnated into the template, reducing the loss of carbon source.A simple soft-template route had been developed to synthesize magnetic Fe-containingOMCs (Fe/OMCs) through multi-component cooperative assembly process, whereinphenolic resin was used as a carbon precursor, triblock copolymer F127as a template agent, tetraethylorsilicate (TEOS) as a silica precursor and hydrated iron nitrite as an iron source.The ordering, the specific surface area and the total pore volumes increased with theincrease of carbonization temperature from600to850°C, but decreased with the increaseof Fe(NO3)3·9H2O loading amount. The specific surface area and the total pore volumesincreased with the increase of TEOS loading. The saturation magnetization strength couldbe easily adjusted by changing the amount of Fe(NO3)3·9H2O. When the content of ironwas10%, TEOS was2.08g and the calcination temperature was850℃, the materials hadoptimized structure parameters and saturation magnetization.The adsorption and desorption properties of the different iron content magnetic OMCssynthesized by hard-templating and soft-templating were investigated and evaluated.Ibuprofen, aspirin, indomethacin, chloramphenicol and dynorphinA(1-13) were used asmodel drugs, respectively. The experimental results showed that the loading degree ofibuprofen, aspirin, indomethacin, chloramphenicol and dynorphin A(1-13) on the seletedOMCs were30%,32.3%,44.5%,34.6%,65.4%, and the desorption rate of the drugs were75.5%,37.1%,24.8%,38.2%,10%, respectively. The loading degree and the desoption ratewere related with the specific surface area, pore volume and pore size. With the increasingof specific surface area and pore volume, the loading degree increased and desorption ratedecreased. With the increasing of pore size, the loading degree decreased and the desorptionrate increased. Korsmeyer-peppas equation f=ktnwas used to fit the desorption curve. Theresults showed that with the increasing of specific surface area and the pore volume, thedesorption constant f increased and the desorption index n decreased. |
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