Peripheral Pathway Involved In The Short Pulse Gastric Electrical Stimulation On Improving The Gastric Sensory Function Of The Rats

Objective The aim of this study were to investigate whether the5HT1A receptor participate in mediating the effect of short pulse gastricelectrical stimulation on improving the gastric sensory function.Methods To investigate the effect of short-pulse gastric electricalstimulation on the expression of5HT1A receptor in nodose and jugularganglia: Eighteen healthy S-D rats were divided into short-pulse gastric electrical stimulation group、long-pulse gastric electrical stimulation group(shamgroup) and the control group，given/not given gastric electrical stimulationindividually，then the number of5HT1A receptor-positive neuron andtracer-positive neuron in each group were detected by immunofluorescenceand neural tracing techniqueResults In the tracer-positive neuron in short-pulse gastric electricalstimulation group, the number of5HT1A receptor-positive neurons was8.25±12.08, which was significantly lower than those in long-pulse gastricelectrical stimulation group (9.55±11.33) and the control group（11.58±14.52）（P<0.05). The number of5HT1A receptor-positive neuronsin the long-pulse gastric electrical stimulation group and the control groupwere no different (P>0.05).Conclusions The present study found the change of5HT1Areceptor-positive neuron in jugular and nodose induced by short pulse gastric electrical stimulation, which suggested that5HT1A receptor might participatein mediating the effect of short pulse gastric electrical stimulation onimproving the gastric sensory function.