Relations Between Non-alcoholic Fatty Liver And Cardiac Structure And Function In Patients With Type2Diabetes Mellitus

Objective: To assess the association between cardiac function and structure andnonalcoholic fatty liver disease (NAFLD) in patients with Type2diabetesmellitus(T2MD)methods：219patients with T2MD were collected from TongJi hospital to make aretrospective analysis. Patients were devided into two groups based on NAFLD(diagnosed by B ultrasonic echograph): T2DM with NAFLD (36female,65male) andT2DM(53female，65male). After their clinical data was recorded, statistical analysiswere done by SPSS20software.result： Age、 sex、 diabetes duration were not significantly different in the twogroups.When compared with the T2DM group, weight, HOMA-IR, HOMA-β, FINS,1hINS,2hINS,3hINS, FCP,1hCP,2hCP,3hCP, TG, ALT, UA were higher and HDL werelower inT2DM with NAFLD group（P＜0.05), FPG,1hPG,2hPG,3hPG, TC, AST leveldidn’t reach statistic significant. In addition，NAFLD patients have greater LVM, greaterLAD, greater LVPW and lower E/A, lower E（P＜0.05). Using logistic regressionanalysis, It was found that after multivarible adjustment, NAFLD was significantlycorrelated with cardiac hypertrophy（OR1.75,95%CI1.05，2.76）, but not for diastolicdysfunction.Conclusion: T2DM patients with NAFLD proved to be in a state of metabolicdisturbance and had highter prevalence of cardiac hypertrophy and diastolic dysfunction.In T2DM patients, NAFLD was associated with cardiac hypertrophy independently ofnumerous baseline confounding factors.