Control The Antimicrobial Application On The Influence Of The Hospitalized Neonatal Prognosis

Objective: To study the control antimicrobial application influence onprognosis of neonate in hospital.Methods:244cases in June of2010(Group before control) and332cases in June of2012(Group after control) in the neonatal Ward one of ourhospital, according to “the neonatal critical cases scoring method (draft)”,and divide into Group critical and Group uncritical respectively, then tostudy the clinical data retrospectively.Results:(1)The average DDDs about antibacterial drug of Group aftercontrol (9.76) has dropped than the Group control before (10.77)significantly.(2) The special antibacterial drug usage rate of the Group aftercontrol is lower than the Group before control (13.7%)(P=0.021) in theGroup uncritical, however in Group critical there’s no statistical differencebetween the Group before control and the Group after control (11.8%and18.9%)(P=0.079).(3) The antibacterial drug combination of the Groupbefore control is mainly duplex use (88.5%)，however the Group aftercontrol is single use (76.3%)，and this two groups have statistical difference (P=0.000).(4) The number of the antibacterial drugs change of the Groupafter control (1.02±1.32) is more than the Group before control (0.62±0.97)in Group critical (P=0.005), however in Group uncritical there’s nostatistical difference [(0.47±0.83) and (0.44±0.79)](P=0.761).(5) Thedetection rate of pathogeny of the Group after control (60.4%) is higherthan the Group before control (45.7%) in Group critical (P=0.013)，however in Group uncritical there’s no statistical difference (38.5%and43.4%)(P=0.407).(6) The disease outcome in hospitalization, theprognosis, the hospitalization days and the serious complications ofinfection between the Group before control and Group after control has nostatistical difference (P>0.05).Conclusion: There is a decrease in the average DDDs through controlthe antimicrobial application, and the disease outcome in hospitalization,the prognosis, the hospitalization days and the serious complications ofinfection has no obvious change, prompted that the risk of the burden ofhospital infection and the prognosis did not increase.