The Childhood Abused, Executive Function And SNPs Of DRD2between Adolescents Of Violence Crime Of Children-onset And Adolescents Of Violence Crime Of Adolescents-onset

Objective:1.To explore the differences of violence behavior, childhood abused,Childhood neglected and executive function between adolescents ofChildren-onset and Adolescence-onset; and to explore the relationships ofbetween childhood abuse and AO violence and CO violence.2.To explore the difference of the rs1800497and rs1799978SNP ofDRD2of adolescents.3.To explore the effect of rs1800497and rs1799978SNPs of DRD2onviolence and executive function.Methods:1.Using case-control study,110violent crimes teenagers whosedelinquency behavior started from childhood (Children-onset,CO),110violent crimes teenagers whose delinquency behavior started fromadolescents (Adolescence-onset,AO) were recruited from juvenile prisonand110male teenagers came from vocational school were served as control group. All the adolescents were completed to the questionnaires ofgeneral situation (age,nationality,family economic,family structure,occupation of parents,etc), the Wechsler intelligence scale short form(WAIS-S), Aggression Questionnaire,Child Neglected Scale,ChildhoodTrauma Questionnaire-28item Form (CTQ-SF), Stockings of Cambridge(SOC),Intra/Extra dimensional Set Shift (IED) and Spatial WorkingMemory (SWM) in CANTAB. All datas were analyzed by analysis ofvariance or chi-square test.2.The rs1800497and rs1799978polymorphism of DRD2gene of COand AO groups were measured by used SNaPshot SNP technology.Genotype and allele frequency will be analyzed by chi-square test; thedifferences of violence behavior and executive function between CO andAO groups which have the same genotye will be analyzed by t test (If thedata does not conform to the normal distribution will be transform Into thenormal distribution); the differences of violence behavior and executivefunction among difference genotype of CO and AO groups will be analyzedby analysis of variance.Results:1.There was no significant difference in age among the three groups(P>0.05); Control group’s in average education years was significant morethan AO and CO groups (P<0.05),but there wasn’t significant differencebetween AO and CO group; There were significant differences in verbal IQ,operation IQ and total IQ among the three groups(C>AO>CO, P<0.05). 2.There were significant difference in number of parents’ bad habits,dwelling environment, social customs around the family, parenting rearingstyles, parents marital status and relationship, parents’ degree of educationamong the three groups(P<0.05),but no significant difference in Parents’personality and Parents’ occupations among the three groups (P>0.05).3.There were significant difference in the body aggression, verbalaggression, anger and aggression score among the three groups(CO>AO>C,P<0.05),AO and CO groups in indirect aggression were significant morethan normal control group (P<0.05), CO group in animosity was significantmore than AO and normal control groups (P<0.05).4.AO and CO groups in the body neglected, emotional neglected,security neglected, communication neglected, physical abuse, emotional abuse, sexual abuse and neglect total scores and abuse total scoreswere more than control groups(P<0.05);but there was no significantdifference in body neglected and communication neglected between CO group and control group (P>0.05) and no significant difference insexual abuse and abuse total scores between CO group and AO group(P>0.05).5.There were significant differences in14indicators of executivefunction among the three groups (P<0.05).IED: CO group in Pre-ED errors, EDS errors and total errors wasmore than AO and control groups(P>0.05), but stage completed wa s less than AO and control groups(P>0.05)。SOC: CO group in problems solved in minimum moves was less than AO and control groups(P>0.05),and CO groups in mean moves(3-move), mean moves(4-move)and mean moves(5-move) was morethan control group(P>0.05), CO group in mean moves(3-move) andmean moves(4-move) were more than AO group(P>0.05),and CO group in mean initial thinking time of4-move and5-move was less than control group(P>0.05).SWM: CO group was significantly more than AO and control group inerrors of the groups, within errors, total errors and strategy score (P>0.05).the errors of CO group in within errors(6-boxs) and within errors(8-boxs)were more than AO group(P>0.05)and CO group in between errors(8-box)was more than AO group(P>0.05).6.There were significant differences between the two groups in theallele frequencies and genotype of DRD2gene rs1800497and rs1799978polymorphism (P<0.05).there were significant difference of bodyaggression, verbal aggression, anger, indirect aggression and aggression ofscore between two groups in GG genotype of rs1800497(P<0.05); therewere significant difference of body aggression, verbal aggression, angerand indirect aggression, aggression of score between the two groups in TTgenotype of rs1799978(P<0.05). 7.Rs1800497: there were significant differences in Pre-ED errors,stage complete, errors in the groups, total errors and strategy score betweenAO and CO groups in GG genotype of rs1800497(P>0.05), and significantdifferences Pre-ED errors, stage complete, total errors and strategy scorebetween AO and CO groups in AG genotype of rs1800497(P>0.05).rs1799978: there were significant differences Pre-ED errors, EDSerrors,total errors,stage complete,errors in the groups,total errors andstrategy score between AO and CO groups in TT genotype of rs1799978(P>0.05).Conclusion:1.Both CO and AO crime adolescents IQ were lower than ordinaryadolescents, and CO crime adolescents’ IQ were lower than AO crimeadolescents.2. AO individuals are more sensitive to environmental factors, but COindividuals may be easily influenced by genetic factors;Therefore, bothgenetic and environment affect the violent behavior.3.CO crime adolescents and AO crime adolescent show executivefunction deficits，and CO crime adolescents’ is more deficits.4.Aggressive behavior and executive function maybe associated withDRD2gene single nucleotide polymorphisms.