Quantitative Analysis Of The Efficiency Of The Dingxianwan On The Treatment Of Refractory Epilepsy By EEG Spike

Epilepsy is a common neurological disease, which caused great impact on the lives of patients because of repeated episodes cause transient cerebral dysfunction. Long-term use of antiepileptic drugs (AEDs) have serious side effects, causing huge economic burden to patients. To obtain a good therapeutic effect, Dingxianwan, a kind of Traditional Chinese patent medicines, has been used to treat epilepsy in our hospital for three years. Clinical trials in the present study have been divided into two parts, the aim of the study was to evaluate the clinical efficacy in the treatment of partial temporal lobe epilepsy.Clinical trial IObjective:To evaluate the quantitative EEG spikes in reliability evaluation of the effect of epilepsy treatment.Methods:Long-range36-channel video EEG was regularly detected, the EEG discharge times in40patients with refractory epilepsy was compared before and after treatment, and the correlation clinical attack and the EEG were also explored. Results:After surgery, the same patient experienced50%of reduction in the number of tracings discharge, a significant reduction in the number of clinical seizures was associated with the EEG improvement and improved clinical manifestations. Conclusion:The quantitative EEG discharge times can be used as an indicator of the effects of epilepsy treatment.Clinical trials IIObjective:To study the clinical efficacy of the traditional Chinese medicine on the refractory temporal lobe epilepsy. Methods:40outpatients with diagnosis of temporal lobe epilepsy in neurology and neurosurgery were randomized and the surgery was excluded, and characteristics of EEG spikes meet spikes quantitative requirements. The40patients were divided into two groups of20people, one is the group with the oxcarbazepine treatment while the other is treated with DXW combined with oxcarbazepine. Line quantitative EEG spikes were to observe the therapeutic effects in each group of patients before and after treatment.Results:Spikes in the group with DXW combined with oxcarbazepine has a greater reduction in the amount than the one with the single drug oxcarbazepine. And the clinical results in the group with combined drugs were satisfactory. Conclusion:The results of this study show that DXW have a certain effect for refractory temporal lobe epilepsy, and the preliminary research confirmed the clinical and experimental basis for themodernization of Chinese medicine research and provide a new approach for epilepsy patients.