The Prognosis Correlation Analysis Of The Positive-lymph Node Rate In Breast Cancer

Objective: Postoperative accurately predict the recurrence of breast cancer patients andthe risk of death, to develop the best treatment, the relationship between the survival ofpatients. Axillary lymph node metastasis in patients with breast cancer, lymph nodemetastasis is one of the factors of the clinical prognosis. Foreign research reports:positive-lymph node rate is an independent prognostic factor in breast cancer patientsaxillary lymph node metastasis[1]. Through research axillary lymph node-positiveproportion and prognosis of breast cancer, and to provide a basis for axillary lymphnode metastasis of breast cancer prognosis and individualized treatment.Methods: The First Affiliated Hospital of Dalian Medical University, January2002-2009period pathologically confirmed axillary lymph node metastasis in patients withinvasive breast cancer in139cases. Collect the patient’s clinical data, including age,menopausal status, tumor size, histological grade, number of lymph node metastasis,number of lymph node dissection, estrogen receptor, progesterone receptor, Her-2expression, postoperative chemotherapy, radiotherapy, endocrine therapy.139patientswere retrospectively analyzed to study lymph node metastasis in breast cancer patientsPLR and disease-free survival and overall survival correlation. All data SPSS19.0statistical software.Results:1.PLR with tumor size, lymph node metastasis, number, histological grade, pathologicalstage, ER, PR, Her-2expression (P <0.05), independent of age (P=0.928>0.05);2single factor analysis: histological grade, tumor size, number of lymph nodemetastasis, number of lymph node dissection, PLR, pathologic stage, ER, Her-2,chemotherapy, endocrine therapy with patients with DFS and OS (P <0.05); PR (DFS:P=0.007; OS: P=0.109), postoperative radiotherapy (DFS: P=0.043; OS: P=0.221)and DFS, no correlation with the OS; Age (DFS: P=0.632; OS: P=0.062),menopausal status (DFS: P=0.326; OS: P=0.062) and DFS and OS were not correlated.3.Multivariate analysis: PLR is an independent predictor of lymph node metastasis inpatients with breast cancer DFS and OS (DFS: P=0.000<0.05, OS: P=0.000<0.05),postoperative radiotherapy (P=0.003<0.05) is an independent predictor of lymph nodemetastasis in patients with breast cancer DFS indicators.4. PLR performs different groups influence on the prognosis:Cutoff of139patients with axillary lymph node metastasis in breast cancer patientswere divided into three groups to PLR=0.20and0.65, which PLR≤0.20410.20<PLR <0.6547PLR≥0.6551. DFS and OS of the three groups of patients wasstatistically significant (median DFS:49months vs36vs14months, P=0.000<0.05;median OS:78months VS70months vs30months, x2=46.088, P=0.000<0.05).5positive lymph nodes grouping, PLR influence on the prognosis:①lymph node metastasis1-3pieces patient (PN1) A total of73people, according tothe PLR of73patients divided into three sub-groups, which, PLR≤0.20,0.20<PLR<0.65PLR≥0.65the number of4026people,7people. The three subgroups DFS andOS were statistically significant (median DFS:49months vs38months VS24months, P=0.003<0.05median OS:78months vs74months VS24months, P=0.000<0.05).②lymph node metastasis4-9pieces patient (PN2) A total of35of35patients dividedinto three subgroups based on PLR, which PLR≤0.20,0.20<PLR <0.65, PLR≥0.65118people,16people. The three subgroups DFS and OS was not statistically significant(median DFS: the36months vs24.5vs18.5months, P=0.491>0.05; median OS:36months vs39vs49months P=0.692>0.05).③lymph node metastasis in patients≥10pieces (PN3) were obtained from31of31patients divided into three subgroups based on PLR, which PLR≤0.20,0.2<PLR <0.65,the number of PLR≥0.6503people,28people. Three subgroups was not statisticallysignificant DFS and OS was statistically significant (median DFS: the VS11months ofthe34months, P=0.127>0.05, median OS:59months VS26months, P=0.041<0.05).Conclusion:1.PLR with tumor size, number of lymph node metastasis, histological grade,pathological stage, ER, PR, Her-2expression has nothing to do with age.2.PLR independent prognostic factor for lymph node metastasis in patients with breastcancer DFS and OS, PLR is larger, the worse the prognosis. 3.PLR may become a predictor of lymph node metastasis in breast cancer prognosis,provide the basis for individualized treatment for breast cancer.