The Influence Of Hyperlipidemia On A β42at Different Cognitive Level

Objective:the influence of hyprlipidemia on Aβ42at various cognitive levelMethods:Neuropsychological assessments were surveyed in99inpatient who are old than50years old, for example:Montreal Cognitive Assessment-Changsha version, Mini-Mental State Examination, Clinical Dementia Rating(CDR), Activity of Daily Living Scale(ADL), Center for Epidemiological survey(CES-D), etc. Every inpatients were diagnosed base on MCI diagnosis criteria of Chinese Medical Association and dementia diagnosis criteria of ICD-10. Additionally, collection the blood and CSF sample, demographic dates and medical history. Detected concentration of Aβ42, T-Tau, MMP-9in the serum and CSF using by ELISA. Using the chi-square test, one way ANOVA, simple linear correlation to analyze the influence of hyperlipidemia on Aβ42, T-Tau、 MMP-9on various cognitive level.Results:1. In normal cognitive group, the overall mean of CSF-Aβ42was not significant different between with or without hyperlipidemia people, but the mean of CSF-Aβ42in people with hyperlipidemia is higher than people without hyperlipidemia. LDL is significant positively correlated with CSF-Aβ42(P<0.05). TC is positively correlated with CSF-Aβ42.2. In MCI and dementia group, the overall mean of CSF-Aβ42was not significant different between with or without hyperlipidemia people, but the mean of CSF-A(342in people with hyperlipidemia is lower than people without hyperlipidemia. LDL and TC is negatively correlated with CSF-Ap42(P>0.05).3.There is no significant positively correlated between CSF-Aβ42and serum-Aβ42.Conclusion:1.LDL is significant positively correlated with CSF-Aβ42and. TC is positively correlated with CSF-Aβ342in normal cognitive function people2.LDL and TC is negatively correlated with CSF-A(342in MCI and dementia patients.3.There is no linear correlation between CSF-Aβ42and serum-Aβ42.