Clinical Efficacy Of Intensity Modulated Radiation Therapy Combined With Concomitant And Adjuvant Temozolomide In The Treatment For Malignant Glioma

[Objective] To investigate the clinical effects of intensity modulated radiotherapy combined with Temozolomide chemotherapy after operation of cerebral glioma.[methods] A total of101patients with cerebral glioma admitted to XiangYa hospital from2007to2011were divided into two groups.Both groups were given intensity modulated radiotherapy and the experiment group was given additional Temozolomide chemotherapy. Short-term and long-term clinical effects and adverse reactions were compared.[Results] The total efficiency of combination group and radiation only group were respectively67.80%and57.14%, and the difference was not statistically significant (P>0.05).The1-year survival rates of the two group were respectively83.05%and61.90%, and the difference was statistically significant (P <0.05).The median time to recurrence and median survival time of the two groups were respectively23months,24months and10months,16months,and the differences were both statistically significant (P<0.001).There were more adverse reactions in the combination group than in the radiation only group, with no significant difference(P>0.05). KPS score, surgical treatment,histological grade and different treatment after surgery have a certain relationship for the prognosis of patients with malignant gliomas,except the patients’gender and age.[Conclutions] Intensity modulated radiotherapy combined with Temozolomide chemotherapy after cerebral glioma can improve curative effects, is safe and reliable, thereby worthy of wide promotion.Under this condition, KPS scores more than eighty,surgical treatment of microscopic total resection,lower histological grade and the use of intensity modulated radiation therapy combined with concomitant and adjuvant temozolomide were protective factors for the prognosis.The patients’gender and age were not independent factors for malignant glioma prognosis.