Response Of Children’s Lung Fuction To Nebulized Magnesium Sulfate

ObjectiveTo observe the response of the children’s lung function to nebulizedmagnesium sulfate after acetylcholine provocation test, and to compare itwith nebulized albuterol alone and combination of nebulized magnesiumsulfate and albuterol.MethodsA total of three hundred and thirty patients which in the non-acuteexacerbation period of asthma (include clinical remission period andchronic persistent period) in follow-up visit were inhaled acetylcholine forbronchial provocation test, and then for whom result was postive wererandomly divided into three groups: magnesium sulfate group, albuterolgroup, combined therapy group. Patients in all three groups were nebulizedinhalaltion magnesium sulfate, albuterol, or combination of magnesiumsulfate and albuterol respectively. The forced expiratory volume in1second(FEV1) and peak expiratory flow(PEF) were compared at10min and20minafter inhalation different diastolic drugs between each group.ResultsLung function were improved after inhaled different drugs in eachgroup and the value of FEV1and PEF was no statistically significantdifference between each other, and there was a significant improvement inthe increased rate of FEV1and PEF at10min and20min in the magnesiumsulfate group when compared with albuterol group and combined therapygroup respectively (P<0.05), which was no statistically significant difference between albuterol group and combined therapy group. Incomparison of lung function at different time points, there was a significantdifference in the lung function between after nebulized inhalation and afterbronchial provocation test in all three groups, but there just magnesiumsulfate group and combined therapy group has a significant improvement inthe increased rate of FEV1and PEF at10min and20min after inhalationmagnesium sulfate and combination of magnesium sulfate and albuterolrespectively, and the albuterol group was opposite.ConclusionNebulized inhalation magnesium sulfate alone has bronchodilationeffect, but the improvement in FEV1and PEF was not better than nebulizedalbuterol alone.There was no statistically significant difference in theimprovement of lung function between albuterol group and combinedtherapy group after nebulized inhalation albuterol and combination ofmagnesium sulfate and albuterol respectively, and it demonstrated that therewas no synergistic effect of the combination in this study.