The Clinical Research Of Pulsed Radiofrequency Of Dorsal Root Ganglion Combined With Epidural Block In The Treatment Of Post-herpetic Neuralgia

Objective: The aim of this study was to evaluate the efficacy ofpulsed radiofrequency of dorsal root ganglion combined with epidural block inthe treatment of post-herpetic neuralgia (PHN).Methods:60patients sufferingfrom post-herpetic neuralgia were divided randomly into two groups:group Aand B.The group A were treated with nerve block and gabapentin(n=30).Thegroup B were treated with nerve block and gabapentin and combined withpulsed radiofrequency of dorsal root ganglion(n=30).The effects were valuatedby Verbal analogue scale(VAS),Self-Rating Depression Scale(SDS),Self-RatingAnxiety Scale(SAS) and NE content in plasma.Results: The VAS,SDS,SASscores after treatment decrease with time comparing with that before treatmentwithin each group(p＜0.05).After pulsed radiofrequency intervention,theVAS,SDS,SAS scores of Group B were significantly decreased compared withthe group A(p＜0.05).The Norepinephrine(NE) content in plasma of each groupwere significantly increased after treatment(p＜0.05),the NE content in plasmaof group B also were significantly increased compared with the group A(p＜0.05).Conclusion: Both two methods of treatment have evident effect forPHN,but epidural block combine pulsed radiofrequency are better than epidural block alone.With the VAS,SDS,SAS scores decreased,the NE content in plasmawere increased may cause by pain relieved.