Synthesis And Structure Research Of5-amino Pyrazole,1,2,4-diazaphospholes Derivatives And Cu~Ⅱ、Fe~ⅡMetal Complexes

The Fe2+in the HPPD enzyme can be coordinated with4-ethoxycarbonyl-5–amino pyrazole which is the biologicalmetabolization. Two oxygen atoms in the hydroxyl and carbonylgroups participate the coordination which inhibites the activity of theenzyme. By the replacement of–OH to–NH2,4-ethoxy carbonyl-5-amino pyrazole is designed and synthesized in this article. Thereactions of CuⅡ, FeⅡwith the molecular are studied to evaluatecoordination activities. Aromatic ring is substituted bydiazophosphine heterocyclic to synthesize1-(3,5-Disubstituted-1,2,4-Diazaphospholes)-4-(5-aminopyrazole) methanone compounds, whichN，P and O atoms have different coordination activities and modes.Metal complexes based Pyrazole ligands, CuL4Cl2, are widelyapplied in many fileds such as metallopharmaceuticals,metallomesogens and supramolecular chemistitry due to its goodthermal stability. The complexes are synthesized by the reaction ofCuCl2and1H-1,2,4-Diazaphospholes in which there are two N atomsand one P atom.This paper is constituted with two parts:Firstly, two pyrazole derivatives,1,3-dimethyl-4-ethoxycarbonyl-5-amino pyrazole and1-methyl-4-ethoxycarbonyl-5-aminopyrazole are synthesized and their reactions with CuⅡ、FeⅡare studied. Theresult shows that the2-N in the ligand is directly involved incoordination with CuⅡ, FeⅡ, the amino and carbonyl group do notparticipate in the coordination.Moreover, the1-(3,5-Disubstituted-1,2,4-Diazaphospholyl)-4-(5-amino pyrazolyl) methanone compounds are designed andsynthesized. The reactions are established and the machnism isstudied. All the compounds are characterized by NMR, IR and X–Ray.Secondly,1H-3,5-disubstituted-1,2,4-diazaphospholes are reactedwith CuⅡmetalion to obtain new CuL4Cl2metal complexes. Thecomplexes are characterized by NMR and IR.