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The Research Of Laryngeal Cricoid To Numerical Simulation Of Biomechanics

Posted on:2015-03-27Degree:MasterType:Thesis
Country:ChinaCandidate:Y ZhangFull Text:PDF
GTID:2254330428463980Subject:Detection Technology and Automation
Abstract/Summary:PDF Full Text Request
The main function of the cricoid cartilage、thyroid cartilage and cricothyroidjoint in larynx is for breathing and pronunciation. Nowadays, there are about136000cases that patients is suffering from laryngeal cancer and laryngeal trauma, but thelaryngectomy is offen used for advanced patients by the limitations of medicalequipment and conditions, then artificial larynx is implanted. The normal cartilagetissue will be removed during the process of laryngectomy for treatment. The largeresection tends to cause the secondary trauma. However, as the development oftissue engineering and gradually in-depth research of Additive Manufacturing(AM)is going forward, there is a new method proposed for repairment of tissue and organtransplantation in the field of biomedical engineering, namely using the AM’sscaffold to graft and substitute defect tissues. In the field of tissue engineering, themerits of scaffold structure plays a major role in physiological function of organsand tissues to achieve recovery, and the manufacture of tissue scaffold is mainlyimplementation completely by technology of Additive Manufacturing(AM).In the paper, firstly, the image data of normal person’s larynx scanned by CT ispreprocessed, the whole three-dimensional model of the cricoid cartilage thyroidcartilage and cricothyroid joint by MIMICS is obtained. Then organizational modelis handled by separating and smoothing, three-dimensional model of cricoid andthyroid cartilage is vividly rebuild. The model of cricothyroid joint is designed andreconstructed. Two cartilage and joints is modeled by the global to local, so that theefficiency and accuracy of the modeling are improved.The cricoid cartilage is needed to simulate the forces for cricoid pressure duringclinical surgery. The bottom of cricoid arch is fixed, then the load is appliedvertically downward to cricoid along the direction of cricoid plate. Eventually, thescope for fracture risk and the data for heterogeneity manufacturing are obtained.The thyroid cartilage is needed to simulate the forces which are caused in theexternal accidents and vocal tension adjustment in larynx respectively, and its easyfracture site is obtained. It is validated that the mechanical properties of polyurethanematerials can meet the requirements of cartilage.Some questions are arised during manufacturing scaffold, so this paper also shows that the performance of MEM-300-II-type high-temperature depositionmanufacturing equipment is debugged and optimized. The problem for loosedscaffold is solved by using hierarchical control method. The structure of the feedingmechanism of putter is debugged appropriately and the problem is solved, so that aconstant and uniformly speed for feeding is achieved. The problems are caused bytemperature fluctuations in nozzle for nozzle clogged and polyurethane charred areanalyzed and solved. The problem for scan line from nozzle is too small and pull offis solved by trial and error, so that scan line from nozzle is even. In the process ofscaffold manufacturing, continuous feed and stable filament evently is an importantbasis for scaffold, the adhesive material is a key factor in scaffold manufacturing.Finally, the manufacture of high-temperature deposition is used, the scaffold ofcricoid can be produced by using the reconstruction model of cricoid imported toMEM-300-II type equipment. The scaffold of cricoid is also forced for compressingtest so that it meets follow-up studies.
Keywords/Search Tags:tissue engineering, cricoid cartilage, scaffold, debug, finite elementanalysis
PDF Full Text Request
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