The Clinical Observation And Economic Analysis In The Therapeutic Schemes Of Butylphthalide Injection For Acute Cerebral Infarction

Objective: This research combine with butylphthalide to treat acute infarctionand compare the effect of this approach and its economical effect value withnon-combine butylphthalide by the way of cost effectiveness analysis. We estimatewhether combining with butylphthalide is more economical than non-combinebutylphthalideMethods: The topic will be70cases of acute ischemic stroke patients wererandomly divided into two groups: Group A: Combination ButylphthalideGroup(combination butylphthalide injection,ozagrel and Danhong injection); GroupB,Non-combination Butylphthalide Group(combination ozagrel and Danhonginjection). On medication and14days after the stroke drug application, measuringthe United States National Institutes of Health Stroke Scale(NIHSS). Medication,14days,30days,90days,180days after treatment to measure the activities of dailyliving scale.We survey its clinical effort and evaluate economical value with costeffectiveness analysis.Results:(1) Before drug, the NIHSS of two group is non-significant (10.51士3.02vs10.78士2.98， P＞0.05)and14days after the stroke drug application,theNIHSS of Combination Butylphthalide Group and Non-combination ButylphthalideGroup is significant difference (5.80士1.82vs7.35士1.95P＜0.05). Comparisonamong two groups,both of their NIHSS are lower than before14days which prove theeffectiveness of two groups.(2) The total significant efficiency of group A(cured+notable progress) is78.1percent, the total efficiency (cured+notableprogress+progress) is94.9percent; the total significant efficiency of group B is56.2percent, the total efficiency is71.6percent. Compared Group A with Group B thereexists significance in total significant efficiency and total efficiency (P＜0.05).（3）In this study，we can see that two types of treatment programs need264.44±121.23yuan，301.96±131.43yuan for each unit effect. This shows that in two types, the program of group A have the highest efficiency compared with Group B.（4）Thecomparison of the daily living abilities between two groups shown that two groups’daily living abilities at each time point,A group was higher than that in B group. Tocompare the BI index at different time point within each group, the resultshowed that the patients’ BI index were increased progressively with theextension of treatment time. Two groups BI scores reached high level at30days afterand then increased progressively and slowly and reached ended. Cerebral infarctionrecover slowly after3month.Conclusion: It illustrates that combination Butylphthalide can significantly improvethe efficiency and efficient. Besides, Combination Butylphthalide cost little.Therefore,the acute phase of cerebral infarction, combined with Butylphthalide is morereasonable.