Research On The Relationship Between Hearing Loss Degree In Syndrome Of Blood Stasis Of Sudden Deafness And Fibrinogen, Blood Viscosity

Objective:To explore the relationship between degree of hearing loss and fibrinogen, blood viscosity in the syndrome of blood stasis patients with sudden sensorineural hearing loss. It can provide a reference for the study of the pathogenesis and valuable information to judge the severity of disease of sudden sensorineural hearing loss. And it also can provide a laboratory evidence for treatment based on syndrome differentiation to improve the clinical efficacy.Methods:We took the patients with sudden deafness which is mild, moderate, moderately severe, severe, and extreme each20list or both ears with the same degree of hearing loss as an research object according to the results of pure tone audiometry from July2012to February2014in our ENT hospital. We choose100healthy people which came to our hospital for examination of health as control group. And the gender and age in control group which were confirmed no ear disorders through detailed history, specialized examination and audiological examination were similar to sudden deafness group. To explore the differences of fibrinogen, blood viscosity (whole blood high, medium and low shear viscosity) between sudden deafness group and control group before drug treatment. And we alse observed the changes of fibrinogen, blood viscosity (whole blood high, medium and low shear viscosity) with increased degree of hearing loss in patients with sudden deafness.Results:1.The fibrinogen,blood viscosity (whole blood medium and low shear viscosity) in sudden deafness group were significantly higher than the control group, with statistical difference (P<0.05). But there is no statistical difference (P>0.05) in the blood viscosity of whole blood high shear viscosity between the two group2. The degree of hearing loss in patients with sudden deafness was positively correlated to FIB, whole blood and low shear viscosity of blood viscosity. But there is no correlation with whole blood high shear viscosity.Conclusion:1.The fibrinogen and blood viscosity of hemorheology may be involved in the occurrence of sudden deafness.2. The fibrinogen, whole blood medium and low shear viscosity of blood viscosity may provide a reference value to judge the severity of sudden deaf patients.3. The fibrinogen and blood viscosity of hemorheology in a certain estent provide a scientific basis for accurate syndrome differentiation of syndrome in blood stasis of sudden sensorineural hearing loss.