The Studies About Changes Of Thyroid Function In The Acute Phase Of Intracerebral Hemorrhage

Intracerebral hemorrhage is a common acute cerebrovascular disease ofneurology, which has high morbidity and mortality, seriously affecting the patient’slife. Studies at home and abroad have reported significant changes of thyroidhormone in both acute and convalescent period of intracerebral hemorrhage patients.Statistics also show that thyroid hormone levels closely associated with the severity，bleeding site and prognosis of intracerebral hemorrhage patients, but the final answeris vary. The experiment is intended to investigate the changes of serum thyroidhormone levels in the acute phase of intracerebral hemorrhage, and whether usethyroid hormone treat cerebral hemorrhage patients with ESS or not.Obiectives:To investigate the relationship between the severity，bleeding site and prognosis ofintracerebral hemorrhage patients and the levels of thyroid hormone in there serum.Methods:We select67patients which is hospitalized because of intracerebral hemorrhage(supratentorial cerebral hemorrhage) in The First Bethune Hospital of JilinUniversity in period between May2013to November2013. Then we used theConiglobus formula to calculate the hematoma and edema volume and used GCS toassess the severity of the patients. The patients were divided into threegroups——mild group(bleeding volume <10ml or GCS score3-7points), mediumgroup （bleeding volume10-30ml or GCS score8-12points) and criticalgroup(bleeding volume>30ml or GCS score13-15points). At the same time,detected the thyroid hormone levels of these patients on onset of24hours, thenmade use of statistical methods to observe the correlation between severity inpatients with acute intra-cerebral hemorrhage and thyroid hormone levels.Divided the patients into two groups which were thalamic hemorrhage group and non-thalamic hemorrhage group according to the bleeding site. Then comparedthe differences of the two groups in thyroid hormones.Onset of the fourteenth day, calculated the bleeding volume, used GCS toassess the severity of the patients and judged the recovery of the consciousnesspatients. Then compared the changes in thyroid function belong with the absorptionof hematoma, the recovery of the consciousness patients after treatment.Results:（1）The bleeding volume and level of consciousness were closely related toacute period T3in patients with cerebral hemorrhage（p＜0.05）, while the bleedingvolume and level of consciousness had no significant difference with T4、TSH（p＞0.05）.(2) The acute period T3was related to the bleeding site of cerebralhemorrhage patients（p＜0.05）, the thalamic hemorrhage group had lower levels ofT3and TSH.(3) Belonging with the absorption of hematoma and the recovery of theconsciousness patients after treatment T3increased (p <0.05), T4and TSH nosignificant change (p>0.05).Conclusion:(1) The bleeding volume and level of consciousness of cerebral hemorrhage isclosely related to the levels of T3in acute phase while has nothing to do with T4,TSH in acute phase.(2) The thalamic hemorrhage group had lower levels of T3andTSH in acute phase compared to non-thalamic hemorrhage group.(3) Belongingwithe absorption of hematoma and the recovery of the consciousness in patients aftertreatment, T3recoveried also.(4) Treating ICH-ESS patients with additional thyroidhormone may have important clinical significance.