The Clinical Data And The Therapeutic Effect Of Patients With Recurrent Spontaneous Abortion

Objective Recurrent spontaneous abortion (RSA) showed sustained growth in recent years. The epidemiological common incidence rate is1%, but based on clinical experience, we believe that the incidence rate should be higher than1%. The pathogenesis of recurrent spontaneous abortions is unknown, pathophysiology process is unclear. Many experience clinical treatment have been used in the clinical treatment of several common program. Despite a number of studies have reported the treatments to be effective, but it seems that there still a lack of adequate theoretical basis and evidence based medicine proof. All in all, this is an emerging disease, with the changing lifestyle of modern people,that shows increasingly high incidence. And its addition to our traditional abortion theoretical knowledge, little is known, is very significance of the disease. This paper selects a relatively novel perspective, trying to investigate whether primary recurrent spontaneous abortion has some differences between the secondary recurrent spontaneous abortion. Affect of pregnancy history exists for the next pregnancy outcome is relatively clear conclusion. The patients with recurrent abortion are mostly young patients, and the primary is more, which prompted a special mechanism which is different from the general recurrent miscarriage may exist. The women had a normal birth history is still possible to be recurrent spontaneous abortion patients. So our interest is sparked to explore the differences. The possible differences between patient characteristics, the treatment outcome, may can indicate the presence of mechanism differences between primary and secondary recurrent spontaneous abortion. Then promote some questions:is there a difference in the severity of the two conditions? Should we choose different treatment ideas and programs? Does it can be an assessment of the severity of the disease evaluation (There is a lack of such clinical indicators)? And does it can be a reference indicator to expect the result of the treatment and prognosis. In the process of searching native and foreign literature, the studies of secondary recurrent spontaneous abortion are rare. This paper attempts to provide some reference for the study and possible tips of interesting thinking in this directionMethods Choose156cases with recurrent spontaneous abortion from June2012to August2013in Reproductive Center of Shandong University Qilu Hospital (All through ultrasound diagnosed as embryos stopping develop, number^2times). Based on whether they had a normal pregnancy and delivery history in the past, they come into secondary (34cases) and primary (122cases) recurrent spontaneous abortion groups. Analyze their age, weight, BMI, pregnancy history, the number of pregnancy failure and other basic information. After a certain appropriate clinical treatments, telephone them to get pregnancy outcomes:abortion again, normal childbirth, abnormal childbirth and other pregnancy applications. Use SPSS19.0software for statistical analysis, t test using for data statistical method, and categorical variables were analyzed using the chi-square test. P values obtained between the two groups, and draw a appropriate conclusion.Results The BMI, the number of failure pregnancy in the past and other basic information indicators were not significantly different (P>0.05). And the age, number of previous pregnancies exist difference (P<0.05). The causes of the disease in the two groups exist difference (P<0.05).After appropriate treatments (immunotherapy, anticoagulant therapy, chelating monitoring ovulation), the overall treatment outcomes have also no significant difference (P>0.05).Conclusions Primary and secondary recurrent spontaneous abortion patients have no significant difference in the basic conditions. Although there are differences in the age, the number of previous pregnancies in the two kinds of patients, but taking into account the previous pregnancy history of childbirth, these differences do not explain a specific physical condition. For the analysis of treatment outcomes, it seems that secondary recurrent spontaneous abortion is not a disease that differ from primary recurrent spontaneous abortion obviously. Since the limited data sample size, Large sample and better design research are still needed.