Analysis Of Factors Associated With Peripapillary Retinal Nerve Fiber Layer Thickness In Myopia People

Purpose: To measure the changes of thickness of retinal nerve fiber layer (RNFL)by Scanning laser polarimetry with enhanced corneal compensation (GDx ECC) in agroup of healthy Chinese myopic individuals. And explore the association among thethickness of RNFL, diopters and axial length of myopia.Methods: One hundred and fifty-seven eyes of147healthy Chinese myopicindividuals were recruited and three groups were classified by their spherical equivalent(SE) of diopters: low myopia (n=26,-0.5D≥SE>-3.0D), moderate myopia(n=72,-3.0D≥SE≥-6.0D), and high myopia(n=49,-6.0D>SE≥-13.0D). The RNFL thicknessprofile including TSNIT average，superior average and inferior average thicknesses，TSNIT Std.Dev. and NFI were measured by GDx ECC. The RNFL thicknesses amongthree sample groups were performed by one-way analysis of variance (one_wayANOVA).Correlations between RNFL thickness and axial length/SE were evaluated byusing partial correlation analysis.Results：No significant difference in overall RNFL thickness measured with GDxECC was found among the three groups (all p>0.05). No significant correlation wasdetected between axial length/SE and overall RNFL thickness measured with GDxECC. Conclusions: Overall RNFL thickness did not vary with myopic SE or axiallength for GDx ECC. RNFL thickness measurements using GDx ECC may be a usefulparameter to assess and monitor glaucoma damage in myopic subjects.