| Objective:To investigate patients with obstructive sleep apnea syndrome (OSAHS) of type2diabetes (T2DM) Patients with endocrine changes in hormone levels, which conduct research to further understand the mechanisms and changes in the body’s endocrine OSAHS patients.Methods:Inclusion criteria were38to72years of pure T2MD hospital patients, T2DM+OSA patients, pure OSA patients and normal control population. All except unstable clinical disease, gestational diabetes or undergoing renal replacement therapy. Diagnosis of diabetes with fasting blood glucose greater than7mmol/1, taking75g glucose powder or eating bread2H postprandial blood glucose greater than11mmol/1standard select diagnosed with type2diabetes,100patients; OSAHS patients selected for polysomnographic monitoring application for confirmed, and the exclusion of OSAHS whereby patients and100healthy pure OSAHS patients with established; while building associated with OSAHS group of100cases of T2DM patients and normal subjects screened group100cases, a total of400cases of4groups patients. Measurement of height, weight, waist circumference, hip circumference, and body mass index (Body Mass Index, BMI), waist-hip ratio (waist-to-hip ratio, WHR) and fat percentage (percentage of body fat,%FAT). BMI (Body Mass Index, BMI)18.5-25kg/m2as the normal line, as defined in the standard of obese and non-obese group. WHR (waist-to-hip ratio, WHR) hip ratio greater than or equal to0.85man, woman hip ratio greater than0.80is equal to the limits of abdominal obesity. Fat percentage measured by skin fold thickness and bioelectrical impedance analysis (percentage of body fat,%FAT), men value greater than or equal to25%body fat, fat woman values greater than or equal to30%were obese. For the original type2diabetes remained unchanged original treatment regimen, take subjects fasted for10hours overnight on this basis, the next morning8A. M. Take cubical vein blood, serum free three triiodothyronine (FT3), serum free thyroxine (FT4), serum thyroxine (T4), serum triode thyroxin, serum thyrotrophic (TSH), adrenocorticotropic hormone(adreno-cortico-tropic-hormone ACTH), cortical (cortical), serum GH (growth hormone GH). And adopt the same subjects at4PM cubical vein blood on the same day, the second serum cortical (cortical); monitoring indicators recorded include apnea hypopnea index (Apnea.Hypopnea Index, AHI), lowest oxygen saturation (lowest oxygen saturation LOX), etc. while the OSAHS patients were divided according to AHI and night SaO2mild, moderate and severe three groups. Were compared between the four groups, as well as between different levels of OSAHS patients with neck circumference, waist circumference, waist-hip ratio, BMI, age, and serum levels of free triiodothyronine three (FT3), serum free thyroxine (FT4), serum thyroxine (T4), serum triode thyroxin, serum thyrotrophic (TSH), adrenocorticotropic hormone (ACTH), between plasma cortical (cortical), GH (growth hormone GH) and other indicators differences. Results:l.Type2diabetic patients with OSAHS group higher BMI and%FAT, clinical differences were statistically significant (p<0.05). Other indicators (age, waist circumference, waist-hip ratio) showed no clinically significant statistical significance (p>0.05) between the four groups.2.Type2diabetes mellitus OSAHS group FT4higher, statistically significant values(p<0.05). I set other indicators showed no statistically significant.3.again OSAHS by light in weight compared to patients with normal control group, found that with varying degrees of OSAHS disease, FT3levels showed a gradual increasing trend in the difference between the different groups was statistically significant (p<0.05).4.OSAHS patients alone, alone T2DM patients, serum ACTH plasma cortical levels in patients with type2diabetes OSAHS group and the control group showed a positive correlation p<0.05), there are statistically significant.5.Pure and simple in T2DM patients with OSAHS serum GH levels and normal comparison p <0.05), and T2DM with OSAHS group compared with the normal group had no statistically significant correlation between the (p>0.05).Conclusions:1.BMI and%F level1OSAHS patients was significantly higher, and the severity index BMI elevated levels in patients with OSAHS correlated, suggesting that BMI and%F levels associated with OSAHS.2.Type2diabetes patients with OSAHS, although FT4serum concentrations were within the normal range, but higher values, suggesting that type2diabetes patients with metabolic abnormalities OSAHS trend.3. FT4with OSAHS is light in weight there is a close correlation between increased FT4reality OSAHS patients with disease progression and correlation of thyroxine and OSAHS severity.4.OSAHS patients with type2diabetes, while the presence of elevated plasma cortical, and type2diabetes mellitus OSAHS is more obvious, suggesting that cortical may be OSAHS disease and type2diabetes mellitus aggravated, common factors of metabolic disorders appear.5. simple and pure in T2DM patients with OSAHS serum GH levels cancel each other out, type2diabetes is caused by OSAHS group P>0.05the main reason. |
