Performance Analysis Of PGS And Cultivation Experiment Research Of Its Electrospinning Scaffod With BMSCs

poly(glycerol sebacate)(PGS) is a novel biodegradable elastomer, and with its excellent biological performances, degradabilities and mechanical properties, it has been widely applicated in a lot of tissues and organs tissue engineering such as heart, vessle, bone, et al. While electrostatic spinning is a preparation method of tissue engineering scaffolds with the characteristics of conveniency, shotcut, controllable processa and low cost. In this paper, the author reviewed Research progress on electrostatic spinning preparation and application of poly(glycerol sebacate) tissue engineering caffolds.The biodegradable poly(glycerol sebacate) elastomer was synthetized by using1:1and1:2two ratios of glyceryl alcohol and sebacic acid through meltcopolycondensation reaction, with the characterization analysis. Electrospinning of the blend of evorotatory polylactic acid and1:1group of PGS to construct tissue engineering scaffolds. Results show that the PGS elastomer has excellent hydrophilic performance and degradation property, moreover, The average pore size, porosity and water contact angle of PGS/PLLA electrospun films was fit, and (38.4±2.5)°characterized by water contact angle analyzer, respectively. The results show on electrospun PGS scaffolds by PLLA blending modification accord with the basic requirement of the tissue engineering.In order to investigate the biocompatibility between electrospun films of PGS/PLLA and rabbit bone marrow mesenchymal stem cells (BMSCs) in vitro to seed the3rd-generation Rabbit BMSCs onto the electrospun films. In order to analyze the compound degree in vitro by scanning electron microscopy (SEM) and HE stain respectively on5th,10th,15th day after seeded, to observe the morphology and growth situation of BMSCs seeded onto the films. It shows that The Rabbit BMSCs growed with great activity and distributed on the films equally, Electronspun PGS/PLLA fibrous films have good performance in biocompatibility aspect and great potential applications in soft tissue engineering field.