Expression Of Smurf1and Smurf2and Its Significance During Liver Fibrosis Of Human

AIM:To observe the expression of Smurf1,Smurf2,Smad3and Smad7protein in liver fibrosis tissues of human and to evaluate their interaction and themechanism of signals in liver fibrosis.METHODS:Immunohistochemistry was applied to detect the expression ofSmurf1,Smurf2,Smad3and Smad7in9tissues of normal liver and38tissues ofchronic HBV infections.RESULTS:Smurf1,Smurf2,Smad3and Smad7showed widespreadexpression.in the liver parenchymal cells and nonparenchymal cells. Comparingwith normal liver, the expression of Smad3increased significantly（Z=-3.110，P=0.002）, the expression of Smurf2also increased significantly （Z=-2.716，P=0.007），the expression of Smad7decreased significantly in iver fibrosisgroup（Z=-2.899，P=0.004）;the expression of Smurf1had no significant change（Z=-1.399，P=0.162）,it showed no significance.There was significant positivecorrelation between Smad3and the degree of fibrosis （r=0.627，P=0.000）;Smad7was negatively correlated with the degree of fibrosis（r=-0.488，P=0.000）;There was no significant correlation between Smurf1and liver fibrosis （r=-0.064，P=0.670）； There was significant positivecorrelation between Smurf2and the degree of fibrosis r=0.652， P=0.000）.Smurf2was positively correlated with Smad3r=0.523，P=0.000）and negatively correlated with Smad7（r=-0.447，P=0.002）;There was norelationship between Smurf1and Smurf2, Smad3,Smad7（r=-0.008、r=-0.053、r=0.219，all P＞0.05）;There was a negative correlation between Smad3andSmad7（r=-0.389，P=0.007）.CONCLUSION：The increace of Smad3signal and decreasce of Smad7signal may lead to the development of liver fibrosis.The regulation of Smurf1play in the delelopmen of liver fibosis may be limited.Smurf2may play a roleby bidirectional regulation in the progression of liver fibrosis,but the role ofpromoting TGF/Smad singal payhway is outweigh than it’s inhibition.