The Correlation Of Fractional Exhaled Nitric Oxide And Asthma Control

Object:Compared to the traditional technology, such as pulmonary function tests, sputum eosinophil count, exhaled nitric oxide (FeNO) is a new simple, non-invasive, repeatable target testing airway inflammation of asthma. Most studies suggest that normal FeNO concentration is below25ppb, higher than25ppb is thought of having different degrees of airway inflammation. So our research aim to discuss the correlation of exhaled nitric oxide (FeNO)concentration and Asthma Control Test (ACT), thus assessing its clinical significance for diagnosis and treatment of asthma and asthma control.Method:According to inclusion and exclusion criteria, the study come from the Shandong Provincial Hospital outpatient with asthma, according to the Asthma Control Test (ACT or C-ACT) divided into group(full control), group(part of the control),group(uncontrolled), select healthy people as the control group, then their exhaled nitric oxide concentration were measured. Evaluate the correlation of Fractional of Fractional exhaled Nitric Oxide and asthma control.Result:There are103people in total, including77asthma and26healthy persons. The average age of healthy control group is33.7years, its male to female ratio is6:7, the average age of asthma patients is35.7, male to female ratio was41:36. Bronchial asthma in each group and the healthy control group were not statistically different (P>0.05) in age, sex, height, weight and so on. There was a significant difference (P<0.05) between77cases of bronchial asthma patients. The exhaled nitric oxide levels has a significant difference (P<0.05) between77cases of asthma patients and26healthy people. Uncontrolled asthma group (x±is115.40±28.52), part of the control group with asthma (x±s was43.77±5.45) FeNO levels were significantly higher than the control group of asthma completely (x±s22.35±3.45), significantly higher than the healthy control group (x±s is9.27±2.05), and FeNO concentrations of each group with a significant difference (P<0.05). And there is a negative correlation (r=-0.951, P<0.05) between the ACT score and FeNO.Conclusion:1. FeNO levels have important clinical implications in the diagnosis and treatment of bronchial asthma.2. FeNO levels can be used as indicators of airway inflammation control in bronchial asthma patients.3. There is a significant negative correlation between FeNO concentrations in each group of patients with asthma and the Asthma Control Test (ACT) value, FeNO levels in patients with asthma monitoring can be used as evaluation criteria of asthma treatment and recurrence.