Clinical Characteristics And Outcomes Of Patients With Sepsis-induced ARDS In A China Intensive Care Unit

Objective: The aim of this study was to investigate the factors that influenced the outcomes of the patients with sepsis induced ARDS due to the failure in implementing series care bundles. Methods:In this study performed in general ICU at Qilu hospital, all consecutively admitted adult (≥18years) patients who need invasive mechanical ventilation (MV)≥48h were included and the patient data analyzed by trained intensivists during three years. Results:Of the1268patients enrolled,96patients with sepsis induced ARDS were eligible for inclusion criteria during the study period. In both group patients, delayed admission to general ICU was a common problem, ARDS mainly origined from infectious pneumonia due to multi-drug resistance pathogens, lower tidal volume and PEEP was adopted during mechanical ventilation. Compared with survivors group, non-survivor patients were elder, higher baseline disease severity scores and proportion of medical disease, lower PaO2/FiO2and higher peak airway pressure, higher occurrence of septic shock which resulted in risen incidence of acute kidney injury, more daily fluid accumulation and higher proportion of CRRT performance. Conclusions:The compliance of the implementation of critical care bundles was bad, and worsen the patients outcomes. Background: Sepsis is the major cause of ARDS, and consistent and efficient implementation of healthcare bundles has been demonstrated to significantly improve the outcomes of the patients with sepsis induced ARDS. The aim of this study was to investigate the factors that influenced the outcomes of the patients with sepsis induced ARDS due to the failure in implementing series care bundles.Methods: In this study performed in general ICU at Qilu hospital, all consecutively admitted adult (≥18years) patients who need invasive mechanical ventilation (MV)≥48h were included and the patient data analyzed by trained intensivists during three years.Results:Of the1268patients enrolled,96patients with sepsis induced ARDS were eligible for inclusion criteria during the study period. In both group patients, delayed admission to general ICU was a common problem, ARDS mainly origined from infectious pneumonia due to multi-drug resistance pathogens, lower tidal volume and PEEP was adopted during mechanical ventilation. Compared with survivors group, non-survivor patients were elder, higher baseline disease severity scores and proportion of medical disease, lower PaO2/FiO2and higher peak airway pressure, higher occurrence of septic shock which resulted in risen incidence of acute kidney injury, more daily fluid accumulation and higher proportion of CRRT performance.Conclusions:The compliance of the implementation of critical care bundles was bad, and worsen the patients outcomes.