Application Of Synthesis, Characterization And Magnetic Resonance Imaging Of Bimetallic Alloy Of FeCo Magnetic Nanomaterials

Magnetic nanoparticles (NPs) showed broad applications in the fields ofmagnetic resonance imaging (MRI) contrast agents, cellular and bio-molecularseparation, magnetic hyperthermia and magnetic sensors owning to their uniquemagnetic properties. Magnetic resonance imaging, one of the most outstandingapplications of magnetic materials, was currently one of the most powerful in vivoimaging technologies owning to its noninvasive property and multidimensionaltomographic capabilities coupled with high spatial resolution. The use of the contrastagents could clarify images and allow better interpretation. Magnetic resonanceimaging can be achieved without tissue damage, three-dimensional CT scan and highresolution. It can obtain high contrast and information enrichment image in thediagnosis of disease. Thus, efficient MR contrast agent causes it to be hot research.Polymer such as PEG, PAA and PVP are organic nontoxic polymer can be dissolved inwater soluble, their degradation products and animal or human metabolicby-products, can be used for modification of magnetic nanomaterials. This paper iscommitted to the development of alloy nanomaterial application in MRI, and someimportant results were obtained.This chapter uses liquid phase chemical coating on the surface of organicpolymer synthesis reduction method (PEG, PVP and PAA) water soluble FeCo alloynanomaterials, hydrazine hydrate in alkaline environment of metal ions to solubleinorganic salts at the same moment reduced to iron cobalt alloy, because of highpolymer nanomaterial surface modification, the nano material has goodcompatibility and stability of biological, non-toxic side effects on cells and humanbody. Through MTT and MRI characterization of materials, we found the maximumconcentration of FeCo@PAA-A2nanoparticles of100μg/mL and the cells wereincubated for24h the cell survival rate is still higher than90%, the transverserelaxation r2(Fe)=42.323mM-1S-1, FeCo@PAA-A2nanomaterial non-toxic to cellsand high transverse relaxation rate. And further the cell MRI test to verify materialFeCo@PAA-A2. It follows that FeCo@PAA-A2NPs is a well and efficient T2weighted magnetic imaging contrast agents Therefore, FeCo@PAA-A2nanoparticles may beused as an effective T2magnetic resonance imaging contrast agents, in the field ofbiomedical applications in cancer diagnosis.