Methanol - Water System Transition Metal Y Type Zeolite Catalytic Synthesis Of Laminin

Laminine is a kind of kelp in the hypotensive activity of non-protein amino acid, is the main component of natural antihypertensive drugs lower blood pressure, regulate blood lipids, hypoglycemic, anti-clotting, anti-bacterial, anti-viral, immune regulation, anti-tumor, anti-radiation, anti-oxidation, anti-fatigue, a variety of pharmacological effects such as hypoxia, and exhibits many novel features in biochemistry, medicine, catalysis, materials, and its research has attracted widespread attention.In this paper, the raw material L-lysine,dimethyl carbonate green reagent is a methylating agent, methanol-aqueous solvent system, to make the transition metal catalyst is Y-type zeolite, silica gel column chromatography as a main separation means, clean synthesis of laminin. Measured melting point of185.2-187.1℃, specific rotation[α]25D=+12.5o laminin and ninhydrin display purple, with Dragendorff reagent were positive, with sodium tetraphenylborate white precipitate formed.Get the methylation process of optimizing the production line:When NiY zeolite mass fraction of6%, temperature180℃,3h the reaction, producing the most optimal route. When the column chromatography, to determine the n-butanol-acetic acid-deionized water volume ratio of4:5:1,the expansion can be achieved better results.In the synthesis temperature of20℃, aging temperature20℃, aging time of96hours,you can get a smaller grain sieve.